AZ 500mg

Tablet
Azithromycin
Aristo pharma

Other Strength:
- Azithrocin 500mg
- Azmasol 4mg
- Metazine MR 35mg
- CINAZIN 15mg
- CINAZIN PLUS 40mg
- Deflazit 6mg
- Nitazox 500mg
- Terazon 2mg
- Prazolok 1mg
- Prazolok 2mg
- Somazin 500mg
- Sulfazin 500mg
- Canazole 50mg
- Canazole 150mg
- Canazole 200mg
- Citazar 250mg
- Citazar 500mg
- Odazyth 500mg
- Ovazol 2.5mg
- Azithromax 500mg
- Cavazide 300mg+12.5mg
- Cavazide 150mg+12.5mg
- Cavazide 75mg+12.5mg
- Odaz 500mg
- Prazopress 1mg
- Prazopress 2mg
- Prazopress ER 2.5mg
- Prazopress ER 5mg
- Gastrazole 20mg
- AZ 250mg
- Reumazin 500mg
- Azithro 500mg
- Claz 80mg
- Azithrocin 250mg
- Azithrocin 200mg/5ml
- Azithrocin 500mg/vial
- Azmasol 100mcg/puff
- Nazolin 0.05%
- Azelec 20%
- Azin 250mg
- Azin 200mg/5ml
- Azolin 0.025%
- Azolin 0.05%
- Defaz CI 50mg+0.50mg+61.80mg
- Halotaz 0.01%+0.045%
- Azecol
- Azonam 1gm/5ml
- AztaCap 4mg
- Fenazine 25mg/ml
- Nebazin (5mg+500IU)/gm
- Nitazox 100mg/5ml
- Oroconazol 2.5mg+50mg
- Tazoskin 0.1%
- Topicazole 2%
- Topicazole Plus 2%+1%
- Spectazole 1%
- Spectazole N 1%+0.1%
- Antazol Plus (2.6mg+0.0325mg)/spray
- Tazid 500mg/vial
- Tazocilin 4mg/5ml
- Tazocilin (4gm+0.5gm)/vial
- Antazol 0.1%
- Antazol 0.05%
- Omrazol 20mg
- Somazole 20mg
- Azepam 5mg
- Azisan 80mg
- Azisan Plus 40mg+12.5mg
- Cefazid 1gm/vial
- Eazy Jelly (1gm+1.3gm)/50gm
- Elazol 200mg
- Mazic Jr 4.05mg/5ml
- Mercazole 5mg
- Prazole 20mg
- Tazopen (4gm+0.5gm)/vial

Alternative:
- Azithrocin 500mg
- Zimax 500mg
- Rozith 500mg
- Zibac 500mg
- Odazyth 500mg
- Azithromax 500mg
- Verizith 500mg
- Odaz 500mg
- Alzith 500mg
- Zinex 500mg
- Amzith 500mg
- Azithro 500mg
- Benzith 500mg



AZ
Presentation:
As with any antibiotic preparation, observation for signs of superinfection with non-susceptible organisms, including fungi, is recommended. Caution should be exercised when Azithromycin is administered to subjects with severe renal impairment. Azithromycin is principally eliminated via the liver, so caution should be exercised when Azithromycin is administered to patients with impaired hepatic function.

Pharmacology:
AZ contains Azithromycin Dihydrate USP an azalide, a subclass of macrolide antibiotics, for oral administration. Following oral administration, Azithromycin is rapidly absorbed and widely distributed throughout thebody. Azithromycin acts by binding to the 50s ribosomal subunit of susceptible microorganisms and thus interfering with microbial protein synthesis. Azithromycin is active against both Gram-positive and Gram-negative microorganisms.

Indications:
AZ is indicated in lower respiratory tract infections including bronchitis and pneumonia, otitis media and in upper respiratory tract infections including sinusitis and pharyngitis/tonsillitis, skin and soft tissue infections, mild to moderate typhoid due to multiple-antibacterial resistant organisms, cholera in children & adult and sexually transmitted diseases both in men and women. Azithromycin is also indicated for the treatment of uncomplicated genital infections due to Chlamydia trachomatis and urethritis and cervicitis due to Chlamydia trachomatis and Neisseria gonorrhoea.


Dosage & Administration:
AZ Tablet & Taste Masked Powder for Suspension may be taken with or without food.
Adult: For sexually transmitted disease caused by Chlamydia trachomatis the dose is 1 g as a single close. For all other indications, the total dose is 1.5 g which should be given as 500 mg daily for 3 days or initially, 500 mg as a single doses followed by a 250 mg single daily dose for the next 4 days. For typhoid fever, the dose is 500 mg once daily for 14 days.
Elderly: Normal adult dose is recommended.

Children > 6 months: The usual dose is 10 mg/kg body weight as a single daily dose for three days: for body weight 15-25 kg, 200 mg or 5 ml/day for 3 days: body weight 26-35 kg, 300 mg or 7.5 ml/day for 3 days: body weight 36-45 kg, 400 mg or 10 mI/day for 3 days. For typhoid fever 10 mg/kg body weight once daily for 7 days or 20 mg/kg body weight once daily for 5 days.
Children < 6 months: Not recommended.

Contrainidications:
AZ is contraindicatd in patients with known hypersensitivity to Azithromycin, erythromycin or any of the macrolide antibiotics.

Warning & Precautions:
It is indicated for topical ophthalmic use only and should not be administered systemically, injected subconjunctivally or introduced directly into the anterior chamber of the eye.
Use in pregnancy:
There are no adequate and well-controlled studies in pregnant women. Thus, it should be used during pregnancy only if clearly needed.
Use in lactation:
It is not known whether Azithromycin is excreted in human milk. Caution should be exercised when Azithromycin ophthalmic solution is administered during lactation.
Pediatric use:
The safety and effectiveness of Azithromycin ophthalmic solution in pediatric patients below 1 year of age have not been established. But in a clinical study it was found that Azithromycin 1% Ophthalmic Solution may be given to neonates for the treatment of ophthalmia neonatorum.

Side effects:
AZ is well tolerated with a low incidence of side effects. Majority of the side effects are mild to moderate in nature and of gastro-intestinal in origin with nausea, abdominal discomfort, vomiting, flatulence and diarrhoea. Allergic reactions such as rash have occurred and there have also been rare reports of serious hypersensitivity reactions. Reversible elevations in liver transaminase have been seen with a frequency similar to the comparative macrolides and penicillins used in clinical trials.

Drug interaction:
Antacids: in patients receiving Azithromycin and antacid. Azithromycin should be taken at least 1 hour before or 2 hours after antacid. Cyclosporin & Digoxin: Macrolides interfere with the metabolism of cyclosporin & digoxin. Ergot derivatives: Because of the theoretical possibility of ergotism, Azithromycin and ergot derivatives should not be coadministered. Terfenadine: As with other macrolides. Azithromycin should be administered with caution in combination with terfenadine.
Overdose: Adverse events experienced in higher than recommended doses were similar to those seen at normal doses. The typical symptoms of an overdose with macrolide antibiotics include reversible loss of hearing, severe nausea, vomiting and diarrhoea. In the event of overdose, the administration of medicinal charcoal and general symptomatic treatment and supportive measures are indicated.

Use in special groups:
There are no adequate and well-controlled studies in pregnant women. Thus, it should be used during pregnancy only if clearly needed.

Storage:
Store in a cool & dry place, protect from light. Keep out of the reach of children.

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