Zinex 500mg

Tablet
Azithromycin
Alco Pharma

Other Strength:
- Zinex 250mg

Alternative:
- Azithrocin 500mg
- Zimax 500mg
- Rozith 500mg
- Zibac 500mg
- Odazyth 500mg
- Azithromax 500mg
- Verizith 500mg
- Odaz 500mg
- Alzith 500mg
- Amzith 500mg
- AZ 500mg
- Azithro 500mg
- Benzith 500mg



Zinex
Description:
Zinex (Azithromycin) is a semi-synthetic antibiotic belonging to the Macrolide class. It is a broad spectrum Antibiotic.

Composition:
Zinex 250 Tablet: Each film coated tablet contains Azithromycin Dihydrate USP equivalent to Azithromycin 250 mg.

Zinex 500 Tablet: Each film coated tablet contains Azithromycin Dihydrate USP equivalent to Azithromycin 500 mg.

Zinex 15 ml PFS: Each 5ml reconstituted suspension contains Azithromycin Dihydrate USP equivalent to Azithromycin 200 mg.

Zinex 30 ml PFS: Each 5ml reconstituted suspension contains Azithromycin Dihydrate USP equivalent to Azithromycin 200 mg.

Zinex 50 ml PFS: Each 5ml reconstituted suspension contains Azithromycin Dihydrate USP equivalent to Azithromycin 200 mg.

Pharmacology:
Zinex (Azithromycin) acts by binding to the 50s ribosomal subunit of susceptible organisms and thus interferes with microbial protein synthesis. Zinex (Azithromycin) demonstrated activity in vitro, against a wide range of Gram-positive and Gram-negative bacteria including: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes (Group A) and other Streptococcus specie; Haemophilus influenzae and parainfluenza;, Moraxella catarrhalis; anaerobes including Bacteroides fragilis, Escherichia coli, Bordetella pertussis and parapertussis, Borrelia burgdorferi, Haemophilus ducreyi, Neisseria gonorrhoeae and Chlamydia trachomatis. Zinex (Azithromycin) also demonstrates activity against Legionella pneumophila, Mycoplasma pneumoniae and hominis, Campylobacter spp., Toxoplasma gondii and Treponema pallidum.

Indication/Use:
Zinex (Azithromycin) is indicated for infections (caused by susceptible organisms) in lower respiratory tract infections including bronchitis and pneumonia, in upper respiratory tract infections including sinusitis, pharyngitis, tonsillitis, otitis media & in skin and soft tissue infections. In sexually transmitted diseases in men and women including non-gonococcal urethritis, cervicitis due to chlamydia trachomatis.

Dosage Guideline:

Zinex tablet can be taken with or without food. Zinex suspension should be taken at least 1 hour before or 2 hours after meal.

Adults: For lower respiratory tract infections including bronchitis and pneumonia, upper respiratory tract infections including sinusitis and pharyngitis/tonsillitis, otitis media and skin and soft tissue infections, the total dose of Zinex is 1.5 gm given as 500 mg once daily for 3 days. An alternative to this dosage schedule is that 500 mg once daily on day 1, followed by 250 mg once daily for next 4 days. For sexually transmitted diseases caused by Chlamydia trachomatis, the dose of Zinex is 1 gm given as single dose. Alternatively, 500 mg once daily on day 1, followed by 250 mg once daily for next 2 days may also be given. For the treatment of cholera caused by Vibrio cholerae, the dose of Zinex is 1 gm as a single dose. For the treatment of uncomplicated gonorrhea (urethritis or cervicitis) caused by Neisseria gonorrhoeae, a single 2 g dose of Zinex may be given. Taking the dose with food may minimize adverse effects. For non-gonococcal urethritis, shigella infection, traveler's diarrhea, the usual oral dosage is 1 gm administered as a single dose. For uncomplicated typhoid fever caused by susceptible salmonella, the dose is 1 gm once daily for 5 days.

Use in the elderly: Normal adult dosage is recommended.

Children: The dose of Zinex in children over 6 months of age is 10 mg/kg body weight once daily for 3 days. Alternatively, 10 mg/kg on day 1, followed by 5 mg/kg for next 4 days is also recommended. Safety and effectiveness in the treatment of children under 6 months of age have not been established. For children the dose of Zinex suspension is as follows:



Body weight (Age)


Dose


Dosage & Duration

Total volume

15-25 kg (3-7 years)

200 mg

5 ml daily for 3 days

15 ml

26-35 kg (8-11 years)

300 mg

7.5 ml daily for 3 days

22.5 ml

36-45 kg (12-14 years)

400 mg

10 ml daily for 3 days

30 ml

As per doctors recommendation

50 ml

For children having body weight over 45kg normal adult dosage is recommended.

Side Effects:
Azithromycin is well tolerated with a low incidence of side effects. The side effects include nausea, vomiting, abdominal discomfort (pain/cramps), flatulence, diarrhoea, headache, dizziness, skin rashes and are reversible upon discontinuation of therapy.

Contraindication:
Azithromycin is contraindicated in patients with a known hypersensitivity to azithromycin or any of the macrolide antibiotics. As liver is the principal route of excretion of azithromycin, it should not be used in patients with hepatic disease.
Avoid concomitant administration with terfenadine or astemizole. Precaution should be taken in patients with more severe renal impairment.

Drug Interaction:
Antacids: Peak serum levels but not the total extent of absorption are reduced by aluminium and magnesium containing antacids in the stomach. Azithromycin should therefore be taken at least 1 hour before or 2 hours after taking these antacids.
Ergot derivatives: Because of the theoretical possibility of ergotism, concomitant administration of ergot derivatives and azithromycin should be avoided.
Digoxin & Cyclosporin: Macrolides have been known to increase the plasma concentration of Digoxin & Cyclosporin and so caution should be exercised while co-administration is necessary.

Use in Pregnancy & Lactation:
Recent clinical studies have recommended that azithromycin should be considered for the initial treatment of chlamydial cervicitis in pregnancy. In other infections, azithromycin should be used only when clearly needed (US FDA pregnancy category B). It is not known whether azithromycin is excreted in breast milk. Exercise caution when administering to nursing women.

Over Dose:
There are no data on overdosage with azithromycin. Typical symptoms of overdosage with macrolide antibiotics include hearing loss, severe nausea, vomiting and diarrhoea. Gastric lavage and general supportive measures are indicated.

Therapeutic Class:
Anti-Infective

Dosage Form:
Tablet & PFS

Storage:

Zinex (Azithromycin) tablets and dry powder for suspension should be stored at room temperature (below 300 C). Any unused portion of reconstituted Zinex suspension should be discarded after 5 days. Store in a cool and dry place, protected from light. Keep out of the reach of children.


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