Pamix Extra 500mg+65mg

Tablet
Paracetamol + Caffeine
Ziska Pharmaceuticals Limited

Other Strength:
- Pamix 500mg

Alternative:
- Fast PLUS 500mg+65mg
- Reset Plus 500mg+65mg
- Ace Plus 500mg+65mg
- Cafedon 500mg+65mg
- Feva Plus Tablet 500mg+65mg
- Xcel Plus 500mg+65mg
- Pyrexil Plus 500mg+65mg
- P+C 500mg+65mg
- Tempanil Extra 500mg+65mg
- Reliv Plus 500mg+65mg
- Benalgin Plus 500mg+65mg



Pamix Extra
Presentation
Pamix extra: Each tablet contains Paracetamol BP 500 mg & Caffeine BP 65 mg.

Description
Pamix extra is the combination of Paracetamol (Acetaminophen) and Caffeine. It has analgesic and antipyretic properties. The presence of Caffeine increases the analgesic effect of Paracetamol. Paracetamol is one of the safest and most widely used analgesic and antipyretic. It produces analgesic action by elevation of the pain threshold and antipyresis through action on the hypothalamic heat regulating center. Caffeine is an alkaloid which is a theophylline like Xanthine derivative. By intermolecular association with Paracetamol, Caffeine increases the solubility and transmembrane permeation of Paracetamol. In addition, caffeine increases the pain threshold and tolerance of pain. Caffeine has also an intrinsic power to raise vessel tone in the cranial nerve of the brain, which provides another benefit to treat migraine and headache.

Indications
Fever, headache, migraine, muscle ache, backache, toothache & menstrual pain

Dosage & Administration
Adults: 1 - 2 tablets every 4 - 6 hours. Maximum dose: 8 tablets daily. Not recommended for children below 12 years.

Side Effects
This combination may cause skin rashes, neutropenia & gastro-intestinal disturbances etc. High dose administration may cause hepatotoxicity.

Precautions
Should be given cautionly in the following cases: In patients with hepatic or renal failure. In patients taking other hepatotoxic medication. Prolonged use of the drug without consulting a physician should be avoided.

Contraindications
Hypersensitivity to Paracetamol, Caffeine or any other components of it

Use in Pregnancy & Lactation
Although there is epidemiological evidence of the safety of Paracetamol in pregnancy & lactation, medical advice should be sought before using this product.

Commercial Packaging
Pamix extra : Each box contains 10 X 20's tablets in blister strip.

Drug Interaction
It increases the effect of chloramphenicol and coumarin anticoagulant. Risk of hepatotoxicity of Paracetamol may be increased in alcoholics or in patients taking other anti-epileptic medications.

Storage
Store in a cool and dry place, protect from light and moisture. Keep all medicines out of reach of the children.

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