Xpa XR 665mg

Tablet
Paracetamol
Aristo pharma

Other Strength:
- Nixpan 20mg
- Nixpan 40mg
- Xpa 500mg

Alternative:
- Napa Extend 665mg
- Fast XR 665mg
- Reset ER 665mg
- Ace XR 665mg
- Xcel ER 665mg
- Benalgin XR 665mg



Xpa XR
Presentation:
Xpa Tablet: Each tablet contains Paracetamol BP 500 mg.
Xpa XR Tablet: Each extended release tablet contains Paracetamol BP 665 mg.
Xpa Suspension: Each 5 ml suspension contains Paracetamol BP 120 mg.
Xpa Paediatric Drops: Each ml Paediatric drops contains Paracetamol BP 80 mg.
Xpa-125 Suppository: Each suppository contains Paracetamol BP 125 mg.
Xpa-250 Suppository: Each suppository contains Paracetamol BP 250 mg.
Xpa-500 Suppository: Each suppository contains Paracetamol BP 500 mg.

Indications:
All conditions requiring relief from pain & fever due to neuritis, neuralgia, headache, migraine, toothache, rheumatic disorder, cold, influenza, dysmenorrhoea, acute & chronic inflammatory disorders.

Extended Release Paracetamol: It is effective for the relief of persistent pain associated with osteoarthritis and muscle aches and pains such as backache. It also provides effective, temporary relief of pain and discomfort associated with headache, tension headache, period pain, toothache, pain after dental procedures and cold & flu.

Dosage & Administration:
For Tablet:
Adults: By mouth, 1-2 tablets every 4-6 hours to a maximum of 8 tablets daily.
For Extended Release Tablet: Adult and children over 12 years: 2 tablets, swallowed whole, every 6-8 hours (maximum 6 tablets per day).
For Suspension:
Children: Up to 1 year: 1/2 -1 teaspoonful
1-5 years: 1-2 teaspoonfuls
6-12 years: 2-4 teaspoonfuls
These doses may be repeated every 4-6 hours when necessary (maximum of 4 doses in 24 hours).
For Paediatric Drops:
Neonates & Children:
0-3 Months: 0.5 ml
4-11 Months: 1 ml
12-23 Months: 1.5 ml
2-3 years: 2 ml
4-5 years: 3 ml
The above doses 4 times daily or directed by the physician.
For Suppository: Suppository should be administered rectally.
Children: 3 months-1 year: 60-125 mg
1-5 years: 125-250 mg
5-12 years: 250-500 mg
These doses may be repeated every 4-6 hours as necessary (maximum 4 doses in 24 hours).
Adults & children over 12 years: 500 mg-1 g every 4-6 hours to a maximum of 4 g daily.

Contrainidications:
Paracetamol is contraindicated in patients with a known hypersensitivity to its components.

Warning & Precautions:
Paracetamol should be given with care to patients with impaired kidney and liver function. It should be given with care to patients taking other drugs that affect the liver.

Side effects:
Side effects are usually mild, though haematological reactions have been reported. Skin eruptions have also occurred. Symptoms of overdose include vomiting, gastrointestinal haemorrhage, liver damage, cerebral edema and renal tubular necrosis. Hypoglycemia has been reported after overdoses of Paracetamol.

Drug interaction:
Domperidone & Metoclopramide accelerate the absorption of Paracetamol. Colestyramine reduces the absorption of Paracetamol. Prolonged regular use of Paracetamol possibly enhances anticoagulant effect of coumarins.

Use in special groups:
Use in pregnancy & lactation: Though Paracetamol appears in breast milk & crosses the placenta it causes no harmful effect to breast-fed infants or foetus.



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