Xenap 500mg

Tablet
Naproxen Sodium
Astra Bioparmaceuticals

Other Strength:
- Xenap plus 500mg
- Xenapro Plus 500mg+20mg
- Xenapro 500mg

Alternative:
- Nuprafen 500mg
- Sonap 500mg
- Napryn 500mg
- Anaflex 500mg
- Anaflex SR 500mg
- Napren 500mg
- Napro 500mg
- Naproben 500mg
- Ultranax 500mg
- Napro-A 500mg
- Xenapro 500mg



Xenap
Description:
Xenap is a nonsteroidal anti-inflammatory drug. It exhibits anti-inflammatory, analgesic, and antipyretic activity by inhibiting prostaglandin synthesis. Naproxen Sodium is completely absorbed from the GIT, but the peak plasma concentration is attained about 1-2 hours after ingestion of Naproxen Sodium.

Composition :
Xenap Tablet: Each enteric coated tablet contains Naproxen Sodium BP equivalent to Naproxen 500 mg.
Indication:
Xenap is indicated for the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and juvenile rheumatoid arthritis. Xenap is also indicated for the treatment of tendonitis, bursitis, acute gout, acute musculoskeletal disorder and dysmenorrhea.

Dosage & administration:
Rheumatoid arthritis /Osteoarthritis/ Ankylosing spondylitis: 250 mg or 500 mg twice daily.
Acute gout: 750 mg initially, then 250 mg every eight hours until the attack has passed.
Acute musculoskeletal disorder: 500 mg initially followed by 250 mg at 6-8 hour intervals as needed.
Dysmenorrhea: 500 mg should be given initially followed by 250 mg at 6-8 hour intervals for up to 5 days.
Children: Juvenile rheumatoid arthritis: In children over five years of age at a dose of 10mg/kg/day taken in two doses.

Side effect:
Gastro-intestinal discomfort: Nausea, diarrhea, ulceration.
Hypersensitivity reactions: Bronchospasm, rashes and angioedema.
CNS side effects: Drowsiness, headache, vertigo, tinnitus and photosensitivity.

Contraindication:
The drug is contraindicated in patients with a history of hypersensitivity to aspirin, or any other NSAIDs – which include those in whom attacks of asthma, angioedema, urticaria , rhinitis have been precipitated by aspirin or any other NSAIDs. Xenap should not be admimistered to individuals hypersensitive to Naproxen.

Drug interaction:
Naproxen can reduce the effectiveness of propranolol and other beta-blockers. Probenecid given concurrently increases Naproxen plasma levels and extends its half-life considerably. Concurrent administration of methotrexate may enhance its toxicity due to reduced tubular secretion.
Precaution:
Naproxen should be given under close supervision to patients with a history of gastrointestinal disease. As Naproxen is eliminated to a larger extent (95%) by urinary excretion via glomerular filtration, it should be used with great caution in patients with impaired renal function and the monitoring of serum creatinine clearance is advised in these patients. Naproxen is not recommended in patients having baseline creatinine clearance less than 20 ml/minute.

Use in pregnancy & lactation:
There are no well controlled studies in pregnant women. The drug should not be used during pregnancy unless clearly needed. Because of the possible adverse effects of prostaglandin inhibiting drugs on neonates, use in lactating mothers must be avoided.

Storage:
Store in a cool and dry place. Protect from light and moisture. Keep out of reach of children.

How supplied:
XenapTablet : Each box contains 7 x 4 tablets in alu-pvc blister pack.

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