Xenapro 500mg

Tablet
Naproxen Sodium
Renata Limited

Other Strength:
- Xenapro Plus 500mg+20mg

Alternative:
- Nuprafen 500mg
- Sonap 500mg
- Napryn 500mg
- Anaflex 500mg
- Anaflex SR 500mg
- Napren 500mg
- Napro 500mg
- Xenap 500mg
- Naproben 500mg
- Ultranax 500mg
- Napro-A 500mg



Xenapro
Indications
Naproxen is indicated for the relief of sign and symptoms of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, juvenile arthritis, tendonitis, bursitis & acute gout. It is also indicated for the management of primary dysmenorrhea & pain.
Pharmacology
Naproxen is a non steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic & antipyretic properties. It is rapidly absorbed from the gastrointestinal tract and achieves 95% bioavailability.
Dosage & Administration
Naproxen Tablet-
Rheumatoid arthritis, osteoarthritis and ankylosing spondylitis: The usual dose is 500-1000 mg daily in two divided doses after meals.
Management of pain, primary dysmenorrhea, acute tendonitis & bursitis: Recommended starting dose is 500 mg followed by 500 mg every 12 hours or 250 mg every 6-8 hours. The initial total daily dose should not exceed 1250 mg and thereafter, the total daily dose should not exceed 1000 mg.
Acute gout: Recommended starting dose is 750 mg followed by 250 mg every 8 hours until the attack has subsided.
Naproxen Suspension-
For Juvenile rheumatoid arthritis: The usual dose for children over 2 years is 10 mg/kg/day given as two divided doses at 12-hours intervals. Therapy in children under 2 years of age is not recommended.
Naproxen Gel-
Is to be applied 2-6 times a day as required and is not recommended for use in children.
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Interaction
ACE inhibitors: diminish the antihypertensive effect of ACE inhibitors.
Antacids & Sucralfate: delay the absorption of Naproxen.
Aspirin: increase adverse effects.
Diuretics: reduce the natriuretic effect of Furosemide and Thiazides.
Methotrexate: enhance the toxicity of Methotrexate.
Warfarin: increase the risk of GI bleeding.
Selective Serotonin Reuptake Inhibitors (SSRI): increase the risk of GI bleeding.
Contraindications
Naproxen is contraindicated in patients with known hypersensitivity to Naproxen. It should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. It is contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.
Side Effects
Most frequently reported side effects include following:
Gastrointestinal: Heartburn, abdominal pain, nausea, diarrhea, dyspepsia.
Central Nervous System: Headache, vertigo, drowsiness.
Dermatological: Pruritus (itching), purpura.
Cardiovascular: Edema, palpitation.
Others: Visual disturbances, hearing disturbances.
Pregnancy & Lactation
US FDA pregnancy category of Naproxen is C. So, Naproxen should be avoided in pregnancy & lactation unless the potential benefits to the other outweigh the possible risks to the fetus.
Therapeutic Class
Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Storage Conditions
Keep below 30°C temperature, protected from light & moisture. Keep out of the reach of children.

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