DIROZYL 400mg

Tablet
Metronidazole
ACME Laboratories Ltd

Other Strength:
- Dirozyl 500mg/100ml
- Dirozyl 200mg/5ml
- Dirozyl 200mg

Alternative:
- Filmet 400mg
- Amodis 400mg
- Metra 400mg
- Metro 400mg
- Amirid 400mg
- Menilet 400mg



DIROZYL
Composition : Tablet 200 : Metronidazole BP 200 mg.

Tablet 400 : Metronidazole BP 400 mg.

Suspension : Metronidazole 200 mg / 5 ml.

Suppository : Metronidazole BP 500 mg.

IV Infusion : Metronidazole BP 500 mg / 100 ml (5 mg /ml).

Indication : Amebiasis, urogenital trichomoniasis (both symptomatic and asymptomatic), giardiasis, anaerobic infections, acute ulcerative gingivitis, intra-abdominal infections (peritonitis, intra-abdominal abscess and liver abscess), skin infections, gynaecological infections (endometritis, endomyometritis, tubo-ovarian abscess and post-surgical vaginal cuff infection), bacterial septicaemia, bone and joint infections, CNS infections (meningitis and brain abscess), lower respiratory tract infections (pneumonia, empyema and lung abscess), endocarditis, leg ulcer and pressure sores, prophylaxis of colorectal and pelvic surgery and eradication of Helicobacter pylori in triple therapy with Amoxycillin and Ranitidine.

Dosage & Administration : For Tablets and Suspension :

Indications


Duration of treatment in days


Adults and Children over 10 Years


Children

7-10 years


3-7 years


1-3 years

Invasive intestinal amebiasis


5-10


800 mg thrice daily


400 mg thrice daily


200 mg four times daily


200 mg thrice daily

Asymptomatic amebiasis


5-10


400-800 mg thrice daily


200-400 mg thrice daily


100-200 mg four times daily


100-200 mg thrice daily

Hepatic and extra intestinal Amebic dysentery


5-10


400-800 mg thrice daily


200-400 mg thrice daily


100-200 mg four times daily


100-200 mg thrice daily

Giardiasis


3


2 g once daily


1 g once daily


600-800 mg once daily


500 mg once daily

Trichomoniasis (both the consorts should be treated simultaneously)


7


200 mg thrice daily
or 400 mg twice daily


100 mg thrice daily


100 mg thrice daily


50 mg thrice daily




2


800 mg in the morning and 1.2 g at night










1


Single dose of 2 g










Bacterial vaginosis


7


400 mg twice daily













1


Single dose of 2 g










Acute ulcerative gingivitis


3-7


200 mg thrice daily


100 mg thrice daily


100 mg twice daily


50 mg thrice daily

Leg ulcer and pressure sores


7


400 mg thrice daily










Acute dental infections


3-7


200 mg thrice daily


Anaerobic infections


7


800 mg thrice daily and then 400 mg thrice daily


7.5 mg/kg body weight thrice daily.

For suppository : Anaerobic Infections : Adults : 1 g every 8 hours for 3 days, then 1 g every 12 hours.

Children (5 - 10 years) : 500 mg every 8 hours for 3 days, then every 12 hours, Over 10 years adult dose.

Surgical Prophylaxis : Adults : 1 g 2 hours before surgery; up to 3 further doses of 1 g may be given every 8 hours for high risk procedures.

Children (5 - 10 years) : 500 mg 2 hours before surgery; up to 3 further doses of 500 mg may be given every 8 hours for high risk procedures.

For IV Infusion : Adults and children over 12 years : Infuse 500 mg 8 hourly at a rate of 5ml /minute and a maximum of 4 g should not be exceeded during a 24-hour period. For surgical prophylaxis, administration shortly before surgery should be followed by 8-hourly doses for the next 24 hours.

Children under 12 years : 7.5mg / kg body weight /day every 8 hours at a rate of 5ml / minute.

Triple therapy against H. pylori infection (gastritis, peptic ulcers and gastric cancer) : Two weeks regimen : Dirozyl® (Metronidazole) 500 mg thrice daily plus Moxilin (Amoxycillin) 750 mg thrice daily plus Ranidin (Ranitidine) 300 mg at night or 150 mg twice daily.

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