Carben O 400mg

Tablet
Calcium Orotate Dihydrate
BENHAM pharmaceuticals

Other Strength:
- Carben 500mg
- Carben C 1000mg+327mg+500mg
- Carben D 500mg+200IU
- Carben DS 600mg+400IU

Alternative:
- Calorate 400mg
- Rocal-O 400mg
- Rotacal 400mg
- Rotate 400mg
- Calbostar 400mg



Carben O
COMPOSITION:
Carben O 400 : Each tablet contains Calcium Orotate dihydrate INN equivalent to Calcium Orotate 400 mg.
Carben O 740 : Each tablet contains Calcium Orotate dihydrate INN equivalent to Calcium Orotate 740 mg.

PHARMACOLOGY:
Adequate Calcium in the blood is so vital to a wide variety of bodily functions that human body will not tolerate a deficiency even for short periods. Clinical evidence suggests that Calcium is useful for the prevention and treatment of osteoporosis and associated fractures. PHARMACOKINETICS:
Carben O contains Calcium Orotate, a calcium supplement with a function amino acid chelating ligand orotic acid. Orotic acid assists the transport of calcium through cellular membrane structures facilitating the intracellular uptake of calcium, particularly in bone. Calcium Orotate also helps in the maintenance of healthy cartilage. Further more, Orotate is involved in the synthesis of DNA (deoxyribonucleic acid) and RNA (ribonucleic acid). Calcium Orotate has the high affinity to penetrate complex cell membrane.

INDICATIONS:
1. To prevent or to treat low blood calcium levels.
2. To treat conditions caused by low calcium levels i.e. bone loss
● Osteoporosis
● Post menopausal osteoporosis
● Juvenile osteoporosis
● Senile osteoporosis
● Osteomalacia
● Rickets
3. Hypoparathyroidism
4. Latent tetany
5. Hip joint plastic surgery
6. Many inflammatory diseases like: Arthritis, Spondylitis etc.
7. Pregnant women & nursing mothers
8. Premenstrual syndrome (PMS)
9. Helps in controlling weight by suppressing the habit of frequent appetite
10. Mood swings
11. Cognitive enhancement
12. Protects the heart by enhancing the efficiency of cardiac muscles etc.

DOSAGE AND ADMINISTRATION:
Carben O 400 : As an addition to the daily diet, 2-3 tablets are usually recommended with meal, after meal or as directed by physician. Carben O 740: As an addition to the daily diet 1-2 tablets are usually recommended with meal, after meal or as directed by physician. CONTRAINDICATIONS:
Calcium Orotate is contraindicated in conditions like kidney stone, kidney disease, increased activity of the parathyroid gland, high amount of calcium in urine & blood and extreme loss of body water.

SIDE EFFECTS:
Bloating and swelling in the abdomen are common side effects of calcium orotate. Loss of appetite, constipation, nausea, vomiting, unusual weight loss, headache and increased thirst/urination. Formation of kidney stones may occur infrequently.

PRECAUTIONS:
Precaution is needed if the patient is allergic to calcium orotate. Before using this product in kidney disease, kidney stones, little or no stomach acid (achlorhydria), disease of the pancreas, a certain lung disease (sarcoidosis), difficulty absorbing nutrition from food precaution is needed.

DRUG INTERACTION:
Calcium can decrease absorption of the following drugs when taken together with bisphosphonates, quinolone antibiotics, tetracycline antibiotics, levothyroxine, phenytoin and tiludronate Sodium. Thiazide-type diuretics can interact with calcium supplements, increasing the risks of hypercalcemia and hypercalciuria.

USE IN PREGNANCY AND LACTATION:
During pregnancy and lactation treatment with calborate should always be under the direction of a physician. Women who are pregnant and breast-feeding need more calcium. Pregnancy related high blood pressure is a common and serious risk for women and their babies. Taking supplement of calcium orotate can help to reduce this risk.

OVERDOSE:
Symptoms of over dose may includes nausea/vomiting, weight loss, loss of appetite, constipation, headache, weakness etc, if any of the side effects become serious please talk with physician.

STOTAGE:
Store below 30o C, protect from light and moisture, keep out of the reach of children.

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