Benprox 500mg

Tablet
Ciprofloxacin
BENHAM pharmaceuticals

Other Strength:

Alternative:
- Rocipro 500mg
- Civox 500mg
- Floxabid 500mg
- Quintor 500mg
- Quinocin 500mg
- Ancipro 500mg
- Cipex 500mg
- Dumaflox 500mg
- Flocip 500mg
- Aprocin 500mg
- Ciflocin 500mg
- Ciprocin 500mg
- Cipro-A 500mg
- Neofloxin 500mg
- Flontin 500mg



Benprox
Composition:
Benprox 500 : Each film coated tablet contains Ciprofloxacin Hydrochloride USP. equivalent to Ciprofloxacin 500 mg.
Benprox 750 : Each film coated tablet contains Ciprofloxacin Hydrochloride USP. equivalent to Ciprofloxacin 750 mg.

Benprox 250: Powder for suspension : Each 5 ml contains Ciprofloxacin Hydrochloride USP equivalent to Ciprofloxacin 250 mg.

Descriptions:
Benprox is active against gram negative bacterias live enterobacteriaceae, Pseudomonas aeruginosa and gram positive aerobic bacteria including penicillinase producing and methicillin resistant Staphylococci. The half- life of Ciprofloxacin is 3.5-4.5 hours. After taking of Ciprofloxacin (oral dose), which is excreted in urine contain near about the amount of 30%-50% of Ciprofloxacin within 24 hours as unchanged drug and active metabolism.

Mechanism of action :
Ciprofloxacin is a broad spectrum antibiotic that is active against both Gram-positive and Gram-neagtive bacteria.It functions by inhibiting the two type of topoisomerase II enzymes namely DNA gyrase and topoisomerase IV those are essential for DNA replication, transcription, repair and recombination. Topoisomerase Iv is necessary to separate DNA that has been replicated (doubled) prior to bacterial cell division .With the DNA not being separated the process is stopped,and the bacterium can not divide on the other hand DNA gyrase is responsible for supercoiling the DNA , so that it will fit in the newly formed cells.Both mechanism amount to killing the bacterium ,that is, Ciprofloxacin acts as a bactericide. Indications: Septicemia ,bacteremia,peritonitis,infections in immuno suppressed patients with haematological or solid tumors and infected burns.

Respiratory tract infections : Lobar and broncho pneumonia, acute and chronic bronchitis and empyema.
Urinary tract infections: Uncomplicated and complicated urethritis,cystitis,pyelonephritis ,prostatitis and epididymitis.
Skin and soft tissue infection: Infected ulcers ,wound infections ,abscesses ,cellulitis,otitis externa ,erysipelas and infected burns. Gastrointestinal infections: Enteric fever ,infections diarrhea,shigellosis ,bacteria food poisoning. Infections of the biliary tract: Cholangitis,cholecystitis,empyema of the gall bladder.

Intra-abdominal infections: Peritonitis,intra-abdominal abscesses.
Bone and joint infections: Osteomyelitis, septic arthritis,
Pelvic infections:pelvic inflammatory disease: salpingitis,endometritis.
Ear,nose and throat (ENT) Infections: otitis media,sinusitis, mastoiditis,tonsillitis. Gonorrhea: Gonorrhea caused by beta-lactamase producing Neisseria gonorrhea.

Dosage & Administration:
Adult Dose:
Urinary Tract infections: Acute uncomplicated:250 mg twice daily for 3 days.Mild/Moderate : 250 mg twice daily for 7 to 14 days. Severe /Complicated : 500 mg twice daily for 7 to 14 days.

Chronic Bacterial Prostatitis: 500mg twice daily for 28 days
Lower Respiratry Tract infections:Mild/Moderate :500 mg twice daily for 7 to 14 days.
Severe/Complicated: 750 mg twice daily for 7 to 14 days. Acute sinusitis: 500 mg twice daily for 10 days;
Skin and Skin Structure infection:
Mil/Moderate: 500 mg twice daily for 7 to days.
Severe/Complicated: 750 mg twice daily for 7 to 14 days.
Bone and joint infection:
Mild /Moderate :500 mg twice daily for 4 to 6 weeks.
Intra-Abdominal Infection:500 mg twice daily for 7 to 14 days.

Infectious Diarrhoea:
Mild/Moderate/Severe: 500 mg twice daily for 5 to 7 days. Typhoid Fever : 500 mg twice daily for 10 days.
Urethral & Cervical Gonococcal Infections:Uncomplicated : 250 mg single dose.
Children and adolescents : RTI & GIT infections: Neonate – 15 mg/kg twice daily ,Child ( 1 month -18 years)-20 mg/kg (max 750 mg) twice daily.
UTI: Neonate -10 mg/kg twice daily ,Child ( 1 month -18 years)-20 mg /kg (max 750 mg) twice daily.
Pseudomonas lower respiratory tract infection in cystic fibrosis: Child ( 1 month- 18 years) 20mg/kg ( max 750 mg) twice daily.

Anthrax : ( treatment & post exposure prophylaxis) : Child (1 month -18 years) - 20 mg/kg ( max 750mg ) twice daily.

Use in pregnancy and lactation :
Ciprofloxacin has been shown to cause arthropathy in immature animals and therefore , it’s use during pregnancy is not recommended. Ciprofloxacin is secreted in milk, administration to nursing mothers is not recommended.

Side effects:
Nausea, vomiting, diarrhoea, dyspepsis, abdominal pain, dizziness, headache, tiredness, confusion, convulsions, skin rashes, pruritus, and possible systemic reactions, joint pain, light sensitivity, transient increase in liver enzyme ( especially in patients with history of liver damage),serum bilirubin, urea or serum creatinine . Arthralgia and myalgia may also occur.

Precautions:
Ciprofloxacin should be used with caution in patients with a history of convulsion disorder. Crystalliuria has been observed only rarely. patients should be well hydrade to avoide excessive alkaline in urine. Contraindication: ciprofloxacin is contraindicated in patients who have hypersensitivity to ciprofloxacin or other quinoplones.

Drug interactions:
Concurrent administration of ciprofloxacin with theophyline may lead to elevated plasma concentration of theophylline. Magnesium hydroxide or aluminium hydroxide may interfere with the absorption of ciprofloxacin. So,concurrent administration of this agent should avoided. Probenecid interfere with renal tubular secretion of ciprofloxacin and produce an increase in the level of ciprofloxacin in the serum. Ciprofloxacin may cause superinfection of non-susceptible organisms.

Over dose:
In acute overdose supportive treatment should be given ,including monitoring of renal function.Adequate hydration must be maintained.

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