X-Din 120mg

Tablet
Fexofenadine Hydrochloride
BENHAM pharmaceuticals

Other Strength:
- X-Din 180mg

Alternative:
- Axodin 120mg
- Fexo® 120mg
- Vifas 120mg
- Xofast 120mg
- Fexoral 120mg
- Ritch 120mg
- Afexa 120mg
- Rynofex 120mg
- Alagra 120mg
- Xofedin 120mg
- Axofen 120mg
- Fexon 120mg
- Alanil 120mg



X-Din
COMPOSITION:
X-Din 120 : Each film coated tablet contains Fexofenadine Hydrochloride USP 120mg.
X-Din 180 : Each film coated tablet contains Fexofenadine Hydrochloride USP 180 mg.
X-Din Supension : Each 5 ml suspension contains Fexofenadine Hydrochloride USP 30 mg.
PHARMACOLOGY:
Fexofenadine Hydrochloride is an antihistamine with selective peripheral H1-receptor antagonist activity. Fexofenadine is rapidly absorbed after oral doses with peak plasma concentrations being reached in 2-3 hours. It is about 60 % to 70% bound to plasma proteins. About 5% of the total doses is metabolized, mostly by the intestinal mucosa with only 0.5% to 1.5% of the dose undergoing hepatic biotransformation by the cyto-chrome P450 system. Elimination half-life of 14 hours has been reported although this may be prolonged in patients with renal impairment. Excretion is mainly in the faeces with only 10% being present in the urine. Fexofenadine doses not appear to cross the blood-brain barrier.

INDICATION:
Seasonal Allergic Rhinitis: X-Din tablets are indicated for the relief of symptoms associated with seasonal allergic rhinitis in adults and children 6 years of age and older.
Symptoms to treat effectively: Sneezing, rhinorrhea, itchy nose/palate/throat, itchy/watery/red eyes.
Chronic Idiopathic Urticaria: X-Din tablets are indicated for treatment of uncomplicated skin manifestations of chronic idiopathic urticaria in adults and children 6 years of age and older. X-Din is indicated for treatment of uncomplicated skin manifestations of chronic idiopathic urticaria in children 6 months to 11 years of age. Fexofenadine Hydrochloride significantly reduces pruritus and the number of wheals.

DOSAGE AND ADMINISTRATION:
In case of decreased renal function, care should be taken in dose selection and it may be useful to monitor renal function. CONTRAINDICATION:
Fexofenadine is contraindicated in patients with known hypersensitivity to any of the ingredients.

DRUG INTERACTION:
Plasma concentrations of Fexofenadine have been increased when given with Erythromycin or Ketoconazole. Antacid containing Aluminium and magnesium hydroxide reduces the absorption of Fexofenadine. Fruit juices including grapesfruit may reduce the bioavailability of Fexofenadine and use together should be avoided.
USE IN PREGNANCY AND LACTATION:
There are no adequate and well controlled studies in pregnant women, Fexofenadine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether Fexofenadine is excreted in human milk or not. Caution should be exercised when Fexofenadine is administered to a nursing woman.

STORAGE CONDITION:
Store at a cool and dry place, protect from light & moisture. Keep out ot the reach of children.

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