Afexa 120mg

Tablet
Fexofenadine Hydrochloride
Unimed Unihealth MFG. Ltd

Other Strength:
- Afexa 180mg

Alternative:
- Axodin 120mg
- Fexo® 120mg
- Vifas 120mg
- Xofast 120mg
- Fexoral 120mg
- Ritch 120mg
- Rynofex 120mg
- Alagra 120mg
- Xofedin 120mg
- Axofen 120mg
- Fexon 120mg
- X-Din 120mg
- Alanil 120mg



Afexa

Indications
Fexofenadine Hydrochloride is indicated for the relief of symptoms associated with seasonal allergic rhinitis in adults and children. It is also indicated for the treatment of uncomplicated skin manifestations of chronic idiopathic urticaria.


Therapeutic Class
Non-sedating antihistamines


Pharmacology
Fexofenadine Hydrochloride is an antihistamine with selective peripheral H1-receptor antagonist activity. It is rapidly absorbed after oral administration and peak plasma concentration is reached in 2-3 hours. It does not appear to cross the blood brain barrier.

Dosage & Administration
Seasonal Allergic Rhinitis-

Adults and children 12 years and older:

Tablet: 60 mg twice daily or 120 mg once daily or 180 mg once daily
In case of impaired renal function: 60 mg once daily

Children from 6 to 11 years:

Tablet: 30 mg twice daily or 60 mg once daily
In case of impaired renal function: 30 mg once daily

Children from 2 to 11 years

Suspension: 30 mg or 5 ml twice daily
In case of impaired renal function: 30 mg or 5 ml once daily

Chronic Idiopathic Urticaria-

Adults and children 12 years and older:

Tablet: 60 mg twice daily or 120 mg once daily or 180 mg once daily
In case of impaired renal function: 60 mg once daily

Children from 6 to 11 years:

Tablet: 30 mg twice daily or 60 mg once daily
In case of impaired renal function: 30 mg once daily

Children from 6 months to less than 2 years:

Suspension: 15 mg or 2.5 ml (1/2 tsp) twice daily
In case of impaired renal function: 15 mg or 2.5 ml (1/2 tsp) once daily

Children from 2 to 11 years:

Suspension: 30 mg or 5 ml (1 tsp) twice daily
In case of impaired renal function: 30 mg or 5 ml (1 tsp) once daily

Interaction
Plasma concentration of Fexofenadine Hydrochloride have been increased when given with erythromycin or ketoconazole. Aluminium and magnesium hydroxide containing antacid reduces the absorption of Fexofenadine Hydrochloride.


Contraindications
Contraindicated in patients with known hypersensitivity to Fexofenadine Hydrochloride or any of its ingredients.


Side Effects
Common side effects are headache, fatigue, drowsiness, nausea, dry mouth and gastrointestinal disturbances.


Pregnancy & Lactation
US FDA pregnancy category of Fexofenadine Hydrochloride is C. So, Fexofenadine Hydrochloride should be avoided in pregnancy and lactation unless the potential benefits to the other outweigh the possible risks to the fetus.


Precautions & Warnings
Caution should be exercised in elderly patient and patient with decreased renal function.


Overdose Effects
In case of an overdose, standard measures to remove any unabsorbed drug should be employed. Symptomatic and supportive treatment is recommended. There has been no reported case of an acute overdose of Fexofenadine hydrochloride.


Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.


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