Troniz 500mg

Tablet
Ornidazole
Unimed Unihealth MFG. Ltd

Other Strength:

Alternative:
- Xynor 500mg
- Robic 500mg
- Ornizol 500mg



Troniz
Presentation
Troniz Tablet: White, oval shaped, film coated tablet, having engraved on one side; each tablet contains Ornidazole INN 500mg.

Uses
Ornidazole is a 5-nitroimidazole derivative. It is used in the following conditions-
1. Trichomoniasis
2. Amoebiasis
3. Giardiasis

Dosage and administration
It is administered by mouth in tablets after food.

Trichomoniasis: In trichomoniasis, a single dose of 1.5g (three Troniz tablets) by mouth is given; 5- day courses of ornidazole 500mg (one Troniz tablet) twice daily are also used. Sexual partners should be treated concomitantly. The children’s dose is 25mg per kg as a single dose.

Amoebiasis: In amoebiasis, 500mg of ornidazole (one Troniz tablet) is given twice daily by mouth for 5 to 10 days; children are given 25mg per kg body weight daily as a single dose for 5 to 10 days. Patients with amoebic dysentery may be given 1.5g (three Troniz tablets) as a single daily dose for 3 days; the children’s dose is 40mg per kg daily.

Giardiasis: In giardiasis, 1 or 1.5g of ornidazole (two or three Troniz tablets) is given by mouth as a single daily dose for 1 or 2 days; the children’s dose is 30 or 40mg per kg daily.

Contra-indications, warnings, etc.
Contra-indications: Ornidazole tablets are contra-indicated in patients with a known hypersensitivity to ornidazole and other imidazoles.

Precautions: Peripheral neuropathy, transient epileptiform seizures, and leucopenia have sometimes been associated with prolonged or intensive treatment with ornidazole. Clinical and laboratory monitoring is advised in patients receiving ornidazole for more than 10 days. Dose should be reduced in patients with severe liver disease.

Drug interaction:
Like with other nitroimidazole the possibility of disulfirum like reaction may exist between ornidazole and alcohol. Concomitant oral anticoagulants may increase the risk of haemorrhage due to their diminished metabolism. Ornidazole may decrease the clearance of 5- fluorouracil.

Use in pregnancy and lactation:
There is no evidence of accumulation when used in pregnant women. Some authorities consider that women taking ornidazole should not breast-feed their babies.

Use in hepatic impairment: In view of the prolonged half-life and reduced clearance of ornidazole reported in patients with hepatic dysfunction, the interval between doses should be doubled in patients with severe hepatic impairment.

Use in renal impairment: The elimination of ornidazole is reported to be largely unaltered in patients with impaired renal function. Dosage adjustment is therefore usually unnecessary, although patients receiving haemodialysis should be given a supplemental dose equivalent to one half of the usual dose before dialysis.

Adverse effects: The adverse effects of ornidazole are generally dose-related. The most common are gastro-intestinal disturbances, especially nausea and an unpleasant metallic taste. Vomiting, and diarrhoea or constipation may also occur. A furred tongue, glossitis, and stomatitis may be associated with an overgrowth of Candida. There have been rare reports of antibiotic associated colitis associated with ornidazole; (it is also used in the treatment of this condition). Weakness, dizziness, ataxia, headache, drowsiness, insomnia, and changes in mood or mental state such as depression or confusion have also been reported. Peripheral neuropathy, usually presenting as numbness or tingling in the extremities, and epileptiform seizures are serious adverse effects on the nervous system that have been associated with high doses of ornidazole or prolonged treatment. Temporary moderate leucopenia and thrombocytopenia may occur in some patients receiving ornidazole. Skin rashes, urticaria, and pruritus occur occasionally and erythema multiforme, angioedema, and anaphylaxis have been reported rarely. Other side effects include urethral discomfort and darkening of the urine. Raised liver enzyme values, cholestatic hepatitis, and jaundice have occasionally been reported.

Pharmaceutical precautions
Store in a cool and dry place, protected from light.

Packaging quantities
Troniz tablet: Cartons of 30 tablets in blister.

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