Pantogut 40mg

Tablet
Pantoprazole
Popular Pharmaceuticals Ltd

Other Strength:
- Pantogut 20mg

Alternative:
- Pantobex 40mg
- PROTOCID 40mg
- Pregel 40mg
- Nixpan 40mg
- Pantex 40mg
- Pantodac 40mg
- Prilosec 40mg
- Pantopra 40mg
- Proton-P 40mg
- Pantotop 40mg
- Trupan 40mg
- Protonil 40mg



Pantogut
Indication

Pantoprazole (Pantogut®) is indicated where suppression of acid secretion is of therapeutic benefit. Pantoprazole (Pantogut®) is registered for the following indications:

Peptic ulcer diseases (PUD)
Gastro esophageal reflux disease (GERD)
Treatment of ulcer resistant to H2 receptor antagonists (H2RAs)
Treatment of ulcers induced by non-steroidal anti-inflammatory drugs (NSAIDs)
Gastrointestinal (GI) bleeding from stress or acid peptic diseases
Eradication of Helicobacter pylori (in combination with antibiotics)
Zollinger-Ellison Syndrome
Prophylaxis for acid aspiration during induction of anaesthesia


Dosage & Administration

Dosage Form





Conditions





Dose





Frequency





Duration

20 & 40 mg Tablet





Usually recommended
adult oral dose





40 mg





Once daily





2-8 weeks







Duodenal Ulcer





40 mg





Once daily





2-4 weeks







Gastric Ulcer





40 mg





Once daily





4-8 weeks







Reflux esophagitis





40 mg





Once daily





4-8 weeks







In resistant ulcers





40 mg





Once daily





8 weeks







Eradication of
Helicobacter pylori





40 mg





Twice daily in
combination
with appropriate
antibiotic





1 week







Zollinger-Ellison
syndrome





20 mg





Maximum 8
capsules per day





Up to control acid
secretion. Then the
dose reduced to
normal







Prophylaxis for acid
aspiration syndrome
during Induction of
anaesthesia





20 mg





Given at the evening
before surgery and
repeated again in the
morning of surgery





-







Maintenance therapy





20 mg





Once daily





-

40 mg IV injection





Usually recommended
adult dose





40 mg





Once daily





-







Duodenal ulcer





2-4 weeks







Gastric ulcer





4-8 weeks







Gastro-esophageal
reflux disease





4 weeks



Method of Administration
Injection: Pantogut® IV Injection 40 mg should be given as a slow intravenous injection. The
solution for IV injection is obtained by adding to the vial 10 ml of the solvent provided. After
reconstitution the injection should be given slowly over a period of at least 2.5 minutes at a
maximum rate of 4 ml per minute.
Infusion: For IV infusion reconstitute one sterile single dose vial of Pantogut® injection with
10 ml 0.9% Sodium Chloride to make 10 ml solution containing 4 mg/ml of Pantoprazole
approximately. Subsequently add 10 ml of reconstituted solution containing 4 mg/ml of
Pantoprazole approximately, to 90 ml 0.9% Sodium Chloride Solution or 90 ml of 5%
dextrose solution to make 100 ml solution of 0.4 mg/ml of Pantoprazole approximately. The
resultant infusion should be given intravenously over a period of 2-15 minutes. Do not dilute
to < 0.4 mg/ml. Reconstitute solution and further diluted solution is stable for 6 hours only.
Do not mix with other drugs/ solution.


Precautions

Patients should be cautioned that Pantogut® tablet should not be split or crushed. Neonates and children: No data are available on administration of Pantoprazole (Pantogut®) to neonates and children. In patients with renal disfunction and geriatric patients the daily dose should not exceed 40 mg. Patients with serious hepatic dysfunction a daily dose should not exceed 20 mg.
Use in Pregnancy
During pregnancy Pantoprazole should not be used unless the benefit exceeds the potential risk.
Use in Lactation
There is no information about the safety of Pantoprazole during breast feeding in human. It should only be used during nursing if considered essential.

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