Pantodac 40mg

Tablet
Pantoprazole
Ziska Pharmaceuticals Limited

Other Strength:
- Pantodac 20mg

Alternative:
- Pantobex 40mg
- PROTOCID 40mg
- Pregel 40mg
- Nixpan 40mg
- Pantogut 40mg
- Pantex 40mg
- Prilosec 40mg
- Pantopra 40mg
- Proton-P 40mg
- Pantotop 40mg
- Trupan 40mg
- Protonil 40mg



Pantodac
Presentation
Pantodac delayed release tablet is a preparation of Pantoprazole which is a proton pump inhibitor indicated for the treatment of acid-peptic diseases. Like other proton pump inhibitorsPantodac causes long-lasting inhibition of acid secretion by inactivating the parietal cell H +-K+ ATPase

Description
Pantodac Tablet 20 mg:
Each tablet contains Pantoprazole Sodium Sesquihydrate USP equivalent to
Pantoprazole 20 mg.

Pantodac Tablet 40mg:
Each tablet contains Pantoprazole Sodium Sesquihydrate USP equivalent to
Pantoprazole 40 mg.


Indications
Pantoprazole is indicated where suppression of acid secretion is of therapeutic benefit, it therefore has a role similar to that of H 2 receptor antagonists and omeprazole
Pantodac is indicated for the following purposes :
Duodenal ulcer, benign gastric ulcer, esophagitis/ulceration, Zollinger-Ellision Syndrome, resistant ulcers, eradication of Helicobacter pylori in the treatment of peptic ulcer (in combination with antibiotics) and in the treatment of ulcers induced by Non-Steroidal Antiinflammatory Drugs (NSAIDs)


Dosage & Administration
The usual recommended adult oral dose is 40 mg once daily, preferably in the morning with or without food.
Duodenal ulcer :40 mg daily in the morning for two weeks, continued for further two weeks if not fully healed
Gastric ulcer : 40 mg daily for 4 weeks, continued for further 4 weeks if not fully healed.
Gastro-esophageal reflux diseaes: 40 mg daily in the morning for four weeks, continued for further four weeks if not fully healed 20 mg daily may be continued (long-term management). Increased to 40mg daily if symptoms return
Doudenal ulcer associated with Helicobacter pylori: 40 mg twice daily associated with appropriate antibiotic regimen.
Ulcer induced by Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Pantoprazole 40 mg daily has been used to prevent the formation of gastroduodenal lesions in patients receiving continuous treatment with NSAIDs

Gastro-intestinal bleeding from stress or acid peptic diseases:
The usual adult oral does is 40 mg once daily, preferably in the morning with or without food, if required dose may be increased

Side Effects
Side effects of the proton pump inhibitors include gastro-intestinal disturbances (including diarrhoea, nausea and vomiting, constipation, flatulence, abdominal pain), headache, hypersensitivity reactions (including rash,urticaria, angioedema. bronchospasm), pruritus, dizziness, peripheral oedema, muscle and joint pain, malaise,blurred vision, depression and dry mouth. Proton pump inhibitors decrease gastric acidity and may incerase the
risk of gastro-interstinal infections.


Precautions
Proton pump inhibitors should be used with caution in patients with liver disease, in pregnancy and breast feeding: Before treatment the presence of gastric malignancy should be excluded. No problem with Pantoprazole has been encountered in clinical use in elderly patients. No dosage adjustment of
Pantoprazole is required in patients with renal impairment but prolongation of metabolism leading to a slight rise in peak plasma levels occurs in hepatic cirrhosis and it is recommended that the dosing is reduced to every other day


Contraindications
In patients with known hypersensitivity to Pantoprazole Sodium Sesquihydrate or any excipient of the formulation

Commercial Packaging
Pantodac Tablet 20 mg: Box containing 6xl0's tablets in alu/alu blister pack

Pantodac Tablet 40 mg : Box containing 3xl0's tablets in alu/alu blister pack.


Drug Interaction
Pantoprazole does not react with the cytochrome P-450 system. No drug interaction has been reported in a large series of studies examining reactions with contraceptives, Diazepam, Diclofenac, Ethanol, Caffeine, Metoprolol, Theophylline, Digoxin, Phenytoin. Nifedipine and Warfarin. The absence of drug interactions may
therefore be regarded as an advantage for Pantoprazole


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