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Neurobest 100mg+200mg+200mcg

Tablet
Vitamin B1, B6 & B12
Renata Limited

Other Strength:
- Neurobest (100mg+100mg+1mg)/3ml

Alternative:
- Neurocare 100mg+200mg+200mcg
- TPC 100mg+200mg+200mcg
- Neuro-B 100mg+200mg+200mcg
- B126 100mg+200mg+200mcg
- Povital 100mg+200mg+200mcg
- Neubin 100mg+200mg+200mcg
- Verita-B 100mg+200mg+200mcg
- Neuvital 100mg+200mg+200mcg
- B3 100mg+200mg+200mcg
- Renep 100mg+200mg+200mcg
- Nopath 100mg+200mg+200mcg
- Neobion 100mg+200mg+200mcg
- Astra-N 100mg+200mg+200mcg
- Nins 100mg+200mg+200mcg
- Combomin 100mg+200mg+200mcg



Neurobest
Composition
Each film-coated tablet contains-
Vitamin B1 (Thiamine Mononitrate) 100 mg
Vitamin B6 (Pyridoxine Hydrochloride) 200 mg
Vitamin B12 (Cyanocobalamin) 200 microgram.
Each 3 ml ampoule contains-
Thiamine Hydrochloride (Vitamin B1) 100 mg
Pyridoxine Hydrochloride (Vitamin B6) 100 mg
Cyanocobalamin (Vitamin B12) 1000 mcg.
Indications
Vitamin B1, B6 & B12 is indicated for the treatment of vitamin B1, B6 & B12 deficiency syndrome. It is also indicated for the supportive treatment of neuritis & non-inflammatory diseases of the nerves, e.g.-
Diabetic neuropathy
Peripheral neuralgin
Lumbago
Myalgia
Optic neuritis
Sciatica
Facial neuralgia
Intercostal neuralgia
Spinal pain.
Pharmacology
Vitamin B1 converts carbohydrates, fatty acids and amino acids into energy, promotes healthy nerves, improves mood, strengthens the heart. Vitamin B6 forms RBCs, helps cells to make proteins, manufactures neurotransmitters e.g. serotonin and releases stored forms of energy, helps to prevent CVS diseases and stroke, helps to lift depression and eases insomnia. Vitamin B12 is essential for cell replication and important for RBC production, prevents anemia, helps to prevent depression, reduces nerve pain, numbness, tingling and lowers the risk of heart diseases.

The vitamin ingredients are absorbed well in per oral reception. It is widely distributed to most tissues and appears in breast milk. Within the cell, thiamine is mostly present as diphosphate. Thiamine is not stored to any appreciable extent in the body and amounts in excess of the body’s requirements are excreted in the urine as unchanged thiamine or as metabolites. Pyridoxine, pyridoxal and pyridoxamine are readily absorbed from the GIT following oral administration and are converted to the active forms of pyridoxal phosphate an pyridoxamine phosphate. They are stored mainly in liver where there is oxidation to 4-pyridoxic acid and other inactive metabolites, which are excreted in urine. As the dose increases, proportionally greater amounts are excreted unchanged in the urine.
Dosage & Administration
Tablet: 1-3 Tablets per day or as advised by the physician.

Injection:
In severe (acute) cases: 1 injection daily until the acute symptoms subside or taken as advised by the physician.
In mild cases: 1 injection 2-3 times per week. Ampoules are preferably injected intramuscularly.
Use in children: There is no information on the use of this drug in children.
* চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Interaction
No drug interaction has been reported yet.
Contraindications
Vitamin B1, Vitamin B6 and Vitamin B12 is contraindicated in patients on levodopa therapy, and in patients with hypersensitivity to any of the ingredients of the preparation.
Side Effects
Generally well tolerated but allergic reactions may be observed in few cases.
Pregnancy & Lactation
Oral tablet form is recommended but due to the presence of benzyl alcohol, injection is not recommended during pregnancy & lactation.
Precautions & Warnings
Cyanocobalamin should not be given in patients with subacute degeneration of the spinal cord. Cyanocobalamin is not suitable form of vitamin B12 for the treatment of optic neuropathies associated with raised plasma concentrations of cyanocobalamin.
Overdose Effects
No overdosage symptoms are to be expected in the recommended dosage. If there is known overdose then treatment is symptomatic & supportive.
Therapeutic Class
Specific combined vitamin preparations

Storage Conditions
Keep out of reach of children. Store in a cool (below 25°C temperature) and dry place, protected from light.

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