Axim CV 500mg+125mg

Tablet
Cefuroxime Axetil + Clavulanic Acid
Aristo pharma

Other Strength:
- MAXIMA 20mg
- Maxima MUPS 20mg
- EfaximTM 550mg
- EfaximTM 200mg
- Axim 250mg
- Axim 125mg
- Axim 500mg
- Axim CV 250mg+62.5mg
- Hepaximin 200mg
- Hepaximin 550mg
- Maxima 40mg
- Maxima 40mg/vial
- Aximin 550mg
- Aximin 200mg

Alternative:
- Furotil Plus 500mg+125mg
- Clavurox 500mg+125mg
- Cerox CV 500mg+125mg
- Xiclav 500mg+125mg
- Claviator-CV 500mg+125mg
- Axeclav 500mg+125mg
- Benkill CV 500mg+125mg
- Cefotil Plus 500mg+125mg
- Famiclav 500mg+125mg
- Turboclav 500mg+125mg
- Furoclav 500mg+125mg



Axim CV
Presentation:
Axim CV 250 Tablet: Each film coated tablet contains Cefuroxime Axetil USP equivalent to Cefuroxime 250 mg and Diluted Potassium Clavulanate BP equivalent to Clavulanic Acid 62.50 mg.

Axim CV 500 Tablet: Each film coated tablet contains Cefuroxime Axetil USP equivalent to Cefuroxime 500 mg and Diluted Potassium Clavulanate BP equivalent to Clavulanic Acid 125 mg.

Axim CV Powder for Suspension: After reconstitution each 5 ml suspension contains Cefuroxime Axetil USP equivalent to Cefuroxime 125 mg and Diluted Potassium Clavulanate BP equivalent to Clavulanic Acid 31.25 mg.

Indications:
Axim CV is indicated for the treatment of the following infections caused by susceptible microorganisms:
- Pharyngitis/Tonsillitis caused by Streptococcus pyogenes
- Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae(including beta-lactamase-producing strains), Moraxella catarrhalis(including beta-lactamase-producing strains), or Streptococcus pyogenes
- Acute Bacterial Maxillary Sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae(non-beta-lactamase-producing strains only)
- Acute Bacterial Exacerbations of Chronic Bronchitis and Secondary Bacterial Infections of Acute Bronchitis caused by Streptococcus pneumoniae, Haemophilus influenzae(beta-lactamase negative strains), or Haemophilus parainfluenzae(beta-lactamase negative strains)
- Uncomplicated Skin and Skin-Structure Infections caused by Staphylococcus aureus(including beta-lactamase-producing strains) or Streptococcus pyogenes
- Uncomplicated Urinary Tract Infections caused by Escherichia coli or Klebsiella pneumoniae.
- Uncomplicated Gonorrhea (urethral and endocervical) caused by penicillinase-producing and non-penicillinase-producing strains of Neisseria gonorrhoeae and uncomplicated gonorrhea, (rectal) in females, caused by non-penicillinase-producing strains of Neisseria gonorrhoeae.
- Lyme disease (erythema migrans) caused by Borrelia burgdorferi.
- Septicemia caused by Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae(including ampicillin-resistant strains) & Klebsiella spp.
- Meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae(including ampicillin-resistant strains), Neisseria meningitidis & Staphylococcus aureus(penicillinase and non-penicillinase producing strains)
- Switch therapy (Injectable to oral)

Dosage & Administration:
Patients Indications Dosage Duration (Days)
Adolescents and Adults (13 years and older) Pharyngitis/tonsillitis 250 mg twice daily 5-10
Acute bacterial maxillary sinusitis 250 mg twice daily 10
Acute bacterial exacerbations of chronic bronchitis 250-500 mg twice daily 10
Secondary bacterial infections of acute bronchitis 250-500 mg twice daily 5-10
Uncomplicated skin and skin-structureinfections 250-500 mg twice daily 10
Uncomplicated urinary tract infections 250 mg twice daily 7-10
Uncomplicated gonorrhea 1000 mg Single Dose
Community acquired pneumonia 250-500 mg twice daily 5-10
MDR Typhoid fever 500 mg twice daily 10-14
Lyme disease 500 mg twice daily 20
Pediatric Patients(3 months to 12 years) Pharyngitis/tonsillitis 20 mg/kg/day in 2 divided dose 5-10
Acute otitis media 30 mg/kg/day in 2 divided dose 10
Acute bacterial maxillary sinusitis 30 mg/kg/day in 2 divided dose 10
Uncomplicated skin & skin-structure infections 30 mg/kg/day in 2 divided dose 10
Community acquired pneumonia 30 mg/kg/day in 2 divided dose 5-10
MDR Typhoid fever 30 mg/kg/day in 2 divided dose 10-14
Uncomplicated urinary tract infection 20 mg/kg/day in 2 divided dose 7-10

Direction for reconstitution of suspension:
Shake the bottle well to loosen the powder. Add 60 ml of boiled and cooled water to the dry powder of the bottle. Then shake the bottle well until all the powder is in suspension. The reconstituted suspension must be kept in 2° and 8° C temperature in a refrigerator and should be used within 7 days after reconstitution.

Contrainidications:
Cefuroxime-Clavulanic Acid is contraindicated in patients with known allergy to cephalosporin & in patients with Pseudomembranous Colitis.

Warning & Precautions:
Cefuroxime-Clavulanic Acid should be given with care to patients receiving concurrent treatment with potent diuretics & who have history of Pseudomembranous Colitis.

Side effects:
Generally Cefuroxime-Clavulanic Acid is well tolerated. However, a few side effects like nausea, vomiting, diarrhea, abdominal discomfort or pain may occur. As with other broad-spectrum antibiotics, prolonged administration of Cefuroxime and Clavulanic acid combination may result in overgrowth of nonsusceptible microorganisms. Rarely (<0.2%) renal dysfunction, anaphylaxis, angioedema, pruritis, rash and serum sickness like urticaria may appear.

Drug interaction:
Concomitant administration of probenecid with Cefuroxime-Clavulanic Acid increases the area under the serum concentration versus time curve by 50%. Drug that reduces gastric acidity may result in a lower bioavailability of Cefuroxime and tend to cancel the effect of postprandial absorption.

Use in special groups:
Use in pregnancy: While all antibiotics should be avoided in the first trimester if possible. However, Cefuroxime-Clavulanic Acid can be safely used in later pregnancy to treat urinary and other infections.
Use in lactation: Cefuroxime-Clavulanic Acid is excreted into the breast milk in small quantities. However, the possibility of sensitizing the infant should be kept in mind.

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