Remdevir 5mg/ml

IV Infusion
Remdesivir
Healthcare Pharmaceuticals

Other Strength:

Alternative:
- Bemsivir 5mg/ml
- Ninavir 5mg/ml
- Remdinil 5mg/ml
- Remicov 5mg/ml



Remdevir
Description
Remdevir® is a preparation of Remdesivir. It is an adenosine nucleotide prodrug that distributes into cells where it is metabolized to form the pharmacologically active nucleoside triphosphate metabolite. Metabolism of Remdesivir to Remdesivir Triphosphate has been demonstrated in multiple cell types. Remdesivir Triphosphate act as an analogue of adenosine triphosphate (ATP) and competes with the natural ATP substrate for incorporation into nascent RNA chains by the SARS-CoV-2 RNA-dependent RNA polymerase, which results in delayed chain termination during replication of the viral RNA. Remdesivir triphosphate is a weak inhibitor of mammalian DNA and RNA polymerase with low potential for mitochondrial toxicity.

Authorized Use
Emergency use of Remdesivir for treatment of suspected or laboratory confirmed Corona Virus Disease (COVID-19). Severe disease is defined as patients with an oxygen saturation (spO2) ≤94% on room air or requiring supplemental oxygen or require mechanical ventilation or requiring extracorporeal membrane oxygenation (ECMO). Specifically, Remdesivir is only authorized for hospitalized adult and pediatric patients for whom use of an intravenous agent is clinically appropriate.

Indication:
Emergency use of Remdesivir for treatment of suspected or laboratory confirmed Corona Virus Disease 2019 (COVID-19). Severe disease is defined as patients with an oxygen saturation (SpO2) ≤94% on room air or requiring supplemental oxygen or requiring mechanical ventilation or requiring extracorporeal membrane oxygenation (ECMO). Specifically, Remdesivir is only authorized for hospitalized adult and pediatric patients for whom use of an intravenous agent is clinically appropriate.

Packaging
Remdevir® 100 mg Lyophilized Powder for Injection: Each box contains 1 vial of 100 mg Remdesivir, 1 ampoule of 20 ml sterile water for injection.

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