Parotin 10mg

Tablet
Paroxetine Hydrochloride
ACI Pharmaceuticals

Other Strength:
- Parotin 20mg

Alternative:



Parotin
Description
Parotin® is a preparation of Paroxetine which isa potent and selective inhibitor of 5-hydroxytryptamine (5-HT, serotonin) uptake. Paroxetineworksby enhancing the serotonergic activity in the centralnervous system resulting from inhibition of neuronal reuptake ofserotonin (5-hydroxytryptamine, 5-HT), in addition with blocking the reuptakeof serotonin into human platelets and has only very weak effects on norepinephrine and dopamineneuronal reuptake.

Indication and usage
Parotin®is indicated for-
Major depressive disorder
Panic disorder
Social anxiety disorder
● Obsessive compulsive disorder Panic disorder
● Generalized anxiety disorder Social anxiety disorder
● Post-traumatic stress disorder

Dosage and administration
Adults
● Major depression, social anxiety disorder, post-traumatic stress disorder, generalized anxiety disorder: The recommended dose is 20mg daily, usually to be taken in the morning and maximum dose up to50mg daily. ● Obsessive-compulsive disorder:The initial doseis 20mg daily, usually to be taken in the morning and maximum dose up to60mg daily.
● Panic disorder:The initial doseis 10mg daily, usually to be taken in the morning and maximum dose upto60mg daily.

Elderly
The maximum dose for elderly is 40mg daily.

Children under18years
Paroxetine is not recommended.

Use in pregnancy and lactation
Paroxetine should only be used during pregnancy when strictly indicated. Abrupt discontinuationshould be avoided during pregnancy.Neonates should be observed if maternal use of
paroxetine continues into the later stages of pregnancy, particularly the third trimester.

Small amount of Paroxetineare excreted into breast milkand caution should be exercised when Paroxetine is administered to a nursing woman. In published studies, as no sign of drug effects were observed in infants, breast-feeding can be considered.

Side effects
The most commonside effects aresomnolence, insomnia, agitation, abnormal dreams (including nightmares), increases in cholesterol levels, decreased appetite, dizziness, tremor, headache, blurred vision, yawning, nausea, constipation, diarrhea, vomiting, dry mouth, sweating, sexual dysfunction, asthenia, body weight gain.

The less common side effects arearrhythmias, confusion, urinary incontinence, panic attacks, depersonalization, neuroleptic malignant syndrome-like events, peripheral edema, acute glaucoma, hepatic disorders, priapism, tinnitus, extra pyramidalreactions and withdrawal reactions.

Precautions
Paroxetine should be used withcaution in patients with mania, epilepsy, seizures, bone fracture, diabetes, ECT, glaucoma, cardiac conditions, hyponatraemia, haemorrhage, renal/hepatic impairment.

Contraindications
Paroxetine is contraindicated in patients with a hypersensitivity to Paroxetine or any of the exipients.

Drug interactions
Paroxetine should not be used with pimozide, tyrptophan, drug metabolizing enzyme inducers /inhibitors,thioridazine,alcohol, fosamprenavir/ritonavir, MAOIs, lithium, phenytoin/anticonvulsants, warfarin, drugsaffecting gastric pH, NSAIDs and acetylsalicylic acid.

Pharmaceutical precautions
Keep away from the reach of children. Store in a cool and dry place protected from light. To be taken and sold only on the prescription of a registered physician.

Presentation
Parotin®10 tablet: Each tablet contains Paroxetine 10mgasHydrochloride Hemihydrate BP.
Parotin®20 tablet:Each tablet contains Paroxetine 20mg asHydrochloride Hemihydrate BP.

Packaging
Parotin®10 tablet: Carton of 30tablets in blister pack.
Parotin®20 tablet: Carton of 30tablets in blister pack.


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