Panoz 20mg

Tablet
Pantoprazole
Astra Bioparmaceuticals

Other Strength:

Alternative:
- Pantonix 20mg
- Trupan 20mg
- Pregel 20mg
- Nixpan 20mg
- Pantogut 20mg
- Pantex 20mg
- Pantodac 20mg
- Pantover 20mg
- Prilosec 20mg
- Pantopra 20mg
- Proton-P 20mg
- Pantotop 20mg
- Protocid 20mg



Panoz
Pantoprazole, a substituted benzimidazole, is an inhibitor of gastric acid secretion. Pantoprazole inhibits secretion of gastric acid by blocking the hydrogen – potassium – adenosine triphosphatase enzyme system, the so called ‘Proton Pump’ of the gastric parietal cell. Absorption of Pantoprazole begins only after the tablet leaves the stomach. Peak serum concentration (Cmax) increase in a manner proportional to oral dose from 10 mg to 80 mg.

Composition
Panoz 20 Tablet: Each enteric coated tablet contains Pantoprazole sodium sesquihydrate BP equivalent to Pantoprazole 20 mg.
Panoz 40 Tablet: Each enteric coated tablet contains Pantoprazole sodium sesquihydrate BP equivalent to Pantoprazole 40 mg.

Indications
Gastric ulcer, duodenal ulcer, gastroesophageal reflux disease (GERD), NSAID-induced peptic ulcer, acid hypersecretory conditions including Zollinger-Ellison Syndrome, eradication of Helicobacter pylori (in combination with Antibiotics), ulcer resistant to H2 receptor antagonists.

Dosage & Administration
Gastric ulcer: 40 once daily, Duodenal ulcer: 40 mg once daily
Erosive Esophagitis : 40 mg once daily for 4 to 8 weeks. For those patients who have not healed after 4-8 weeks of treatment, an additional 4-8 weeks course of Pantoprazole may be considered.
Gastroesophageal Reflux Disease: 40 mg once daily up to 8 weeks.
H. pylori eradication for treatment of Duodenal Ulcer: 40 mg Pantoprazole twice daily with 500 mg Clarithromycin and 1 g Amoxicillin twice daily for 7-10 days. NSAID-induced peptic ulcer: 40 mg once daily

Side Effect
Pantoprazole is well tolerated in both short term and long term treatment. Headache and diarrhoea are the most common side effects and rarely included abdominal pain, flatulence, rash, insomnia and hyperglycemia.

Contraindication
Pantoprazole is contraindicated in patients with known hypersensitivity to the active drug or any other components of the formulation.

Drug Interaction
No dosage adjustment is needed with concomitant use of the following: theophylline, cisapride, antipyrine, caffeine, carbamazepine, diazepam, diclofenac, naproxen, piroxicam, digoxin, ethanol, glyburide, oral contraceptive (Ievonorgestrel/ethinyl estradiol), metoprolol, nifedipine, phenytoin, warfarin, midazolam, clarithromycin, metronidazole or amoxicillin. Pantoprazole may interfere with absorption of drugs where gastric pH is an important determinant of their bioavailability (e.g. ketoconazole, ampicillin ester and iron salts).

Precaution
Patients should be cautioned that Pantoprazole tablet should not be split, crushed or chewed. The tablet should be swallowed whole, with or without food in the stomach. Concomitant administration of antacid does not affect the absorption of Pantoprazole.

Use In Pregnancy And Lactation
Pregnancy category B. This drug should be used during pregnancy only if clearly needed. Pantoprazole excretion in human milk has been detected in a study. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the benefit of the drug to the mother.

Storage
Protect from light, store in a cool and dry place, Keep out of reach of children.

How Supplied
Panoz 20 Tablet: Box containing 6 x10’s tablets in Alu-Alu blister pack.
Panoz 40 Tablet: Box containing 5 x10’s tablets in Alu-Alu blister pack.

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