Lincocin 150mg

Capsule
Clindamycin [Oral/Injection]
ACME Laboratories Ltd

Other Strength:
- Lincocin 300mg

Alternative:
- Clinacyn 150mg
- Clindacin 150mg
- Cleocin 150mg



Lincocin
DESCRIPTIONClindamycin is a lincosamide antibiotic used in the treatment of infections caused by susceptible microorganisms. It is a semisynthetic antibiotic produced from lincomycin. Clindamycin is rapidly absorbed after oral administration. Concomitant administration of food does not appreciably modify the serum concentrations. Serum level studies following multiple doses of Clindamycin for up to 14 days show no evidence of accumulation or altered metabolism of drug. Clindamycin is widely distributed in body fluids and tissues (including bones). The average biological half-life is 2.4 hours. No significant levels of Clindamycin are attained in the cerebrospinal fluid (even in the presence of inflamed meninges).Clindamycin is bacteriostatic. It inhibits bacterial protein synthesis by binding to the 50S subunit of the ribosome. It has activity against Aerobic gram-positive cocci, including: Staphylococcus aureus, Staphylococcus epidermidis(penicillinase and non-penicillinase producing strains), Streptococci, Pneumococci. Anaerobic gram-negative bacilli, including: Bacteroides species, Fusobacteriumspecies. Anaerobic gram-positive non-spore forming bacilli including: Propionibacterium species, Eubacterium species, Actinomyces species. Anaerobic and microaerophilic gram-positive cocci, including: Peptococcus species, Peptostreptococcus species, Microaerophilic streptococci, C. perferinges,B. fragilis.

COMPOSITIONLINCOCIN 150:Each capsule contains Clindamycin Hydrochloride BP equivalent to Clindamycin 150 mg. LINCOCIN 300:Each capsule contains Clindamycin Hydrochloride BP equivalent to Clindamycin 300 mg.INDICATIONSSerious Respiratory tract infections including bronchitis, emphysema, pneumonia and lung abscess.Serious skin and soft tissue infection including AcneBone and bone joint infections including osteomyelitis and septic arthritis.Intra-abdominal infections such as peritonitis intra-abdominal abscess.Infection of genital tract infection as endometritis, nongonococcol tuboovarian abscess, Pelvic Infections, pelvic cellulites and post surgical vaginal cuff infection.Septicemia and endocarditis.Dental infection such as periodontal abscess and periodontitis. It is also used as alternative therapy for infection of penicillin-allergic patients caused by penicillin susceptible microorganisms. As combination with Quininesulfatefor the treatment of uncomplicated chloroquine-resistantPlasmodium falciporumMalaria.Clindamycin can also be usedfor infections associated with meticillin-resistant staphylococcus aureous (MRSA) in bronchiectasis, bone and bone joint infections and skin and soft tissue infections.

DOSAGE AND ADMINISTRATIONAdult: Serious infections: 150 to 300 mg every 6 hours. More severe infections: 300 to 450 mg every 6 hours. Children: Serious infections: 8 to 16 mg/kg/day divided into three or four equal doses. More severe infections: 16 to 20 mg/kg/day divided into three or four equal doses.To avoid the possibility of esophageal irritation, LINCOCIN Capsules should be taken with a full glass of water.Or as directed by the physician.SIDE EFFECTSSide effects include diarrhoea (discontinue treatment), abdominal discomfort, Oesophagitis, Oesophageal ulcers, taste disturbances,
nausea, vomiting, antibiotic-associated colitis, jaundice, rash, pruritis and urticaria.

CONTRAINDICATIONSClindamycin is contraindicated in individuals with a history of hypersensitivity to preparations containing clindamycin.PRECAUTIONSDiscontinue immediately if diarrhoea or colitis develops. Monitor liver and renal function if treatment exceeds 10 days. Clindamycin occasionally results in overgrowth of nonsusceptible organisms-particularly yeast. Appropriate measures should be takenif superinfections occur.USE IN CHILDRENWhen Clindamycin is administered to the pediatric population (birth to 16 years), appropriate monitoring of organ system functions is desirable.USE IN PREGNANCY AND LACTATIONPregnancy category B.The drug should be used in pregnancy only if clearly needed. Clindamycin has been reported to appear in breast milk. So it is not recommended for lactating mother if not clearly needed. USE IN ELDERLYPatients should be carefully monitored for the development of diarrhea.DRUG INTERACTIONSAntagonism has been demonstrated between Clindamycin and Erythromycin in vitro. Because of possible clinical significance, these two drugs should not be administered concurrently.SUPPLYLINCOCIN 150: Each box contains 3X10 capsules in blister strips.LINCOCIN 300:Each box contains 3X10 capsules in blister strips.Store in a cool & dry place, protected from light.Keep all medicines out of reach of children.

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