Levonix 500mg

Tablet
Levofloxacin (Oral)
Ziska Pharmaceuticals Limited

Other Strength:

Alternative:
- LEO 500mg
- Trevox 500mg
- Resquin 500mg
- Levobac 500mg
- Leflox 500mg
- Levoday 500mg
- Isovox 500mg
- Leoflox 500mg
- Ovel 500mg
- Levo 500mg
- Benfloxin 500mg
- Levoking 500mg



Levonix
Presentation
Levonix 500 Tablet: Each film coated tablet contains Levofloxacin INN 500 m

Description


Levonix 500 Tablet contains Levofloxacin, a synthetic broad spectrum antibacterial agent for oral administration

PHARMACOKINETICS
Levofloxacin is rapidly and completely absorbed after oral administration. Peak plasma concentrations are usually attained one to two hours after oral dosing. The absolute bioavailability of a 500 mg oral dose of Levonix 500 is approximately 99%. Steady-state is reached within 48 hours following a 500 mg once daily regimen. Penetration of Levonix 500into blister fluid is rapid and extensive.Levonix500 also penetrates into lung tissues. It is mainly bound to serum albumin in humans. Levonix 500 undergoes limited metabolism in humans and is primarily excreted as unchanged drug in the urine. Following oraladministration, approximately 87% of an administered dose was recovered as unchanged drug in urine within 48 hours, where as less than 4% of the dose was recovered in faeces in
72 hour

Indications
It is indicated for the treatment of adults with acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, community acquired pneumonia, skin & skin structure infections as abscess, cellulitis, furuncles, impetigo, pyoderma, wound infections, complicated & uncomplicated urinary tract infections, acute pyelonephriti

Side Effects
The following events are considered likely to be drug related in patients receiving Levonix 500 . Nausea, diarrhea, vaginitis, pruritus, abdominal pain, dizziness, flatulence, rash, dyspepsia, insomnia, moniliasis, taste perversion, vomiting

Precautions
Adequate hydration of patients receiving Levonix 500 should be maintained to prevent the formation of a highly concentrated urine. Excessive exposure to sunlight should be avoided. Therapy should be discontinued if phototoxicity occurs. It should be used with caution in any patient with a known or suspected CNS disorder that may predispose to seizures or lower the seizure threshold. In the patients of symptomatic hyperglycemia & hypoglycemia, careful monitoring of blood glucose is recommended. If a hypoglycemic reaction occurs in a patient being treated with Levonix 500 , it should be discontinued immediately

Contraindications
Levofloxacin is contraindicated in persons with a history of hypersensitivity to it, quinolone antimicrobial agents, or any other components of this product.

Use in Pregnancy & Lactation
Levonix500 should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Levofloxacin is excreted into human milk. Because of the potential for serious adverse reactions from Levonix 500 in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother

Commercial Packaging
Levonix 500 Tablet: Each box contains 3X7's tablets in alu-alu blister pack

Drug Interaction
Antacids containing magnesium, or aluminium as well as sucralfate, iron, & multivitamin preparations with zinc, chewable/buffered tablets or the pediatric powder for oral solution may substantially interfere with the gastro-intestinal absorption of Levofloxacin, resulting in systemic levels considerably lower than desired. Theophylline levels should be closely monitored & appropriate dosage adjustments made when it is co-administered. Adverse reactions, including seizures, may occur with or without an elevation of serum theophylline levels. Suitable anticoagulation test should be closely monitored if Levofloxacin is administered concomitantly with warfarin. The concomitant administration of a non-steroidal anti-inflammatory drug with a quinolone, including Levonix 500, may increase the risk of CNS stimulation & convulsive seizures. Careful monitoring of blood glucose is recommended when antidiabetic agents are co-administered

এই পাতাটি ২৪৩ বার দেখা হয়েছে