Esoben MUPS 20mg

Tablet
Esomeprazole
BENHAM pharmaceuticals

Other Strength:
- Esoben 20mg
- Esoben 40mg

Alternative:
- Opton 20mg
- MAXIMA 20mg
- Maxima MUPS 20mg
- Nexum 20mg
- Sergel 20mg
- Progut 20mg
- Esomep 20mg
- Esopra 20mg
- Emep 20mg
- Esoz 20mg
- Esonix 20mg
- Nexum MUPS 20mg
- Maxpro 20mg
- Maxpro MUPS 20mg



Esoben MUPS
COMPOSITION:
Esoben MUPS 20 : Each Esoben MUPS 20 tablet contains 20 mg Esomeprazole (as Esomeprazole Magnesium Trihydrate USP enteric coated pellets).

MUPS:
MUPS is abbreviation for Multiple-Unit Pellet System. However, from pharmaceutical industry and research perspective, the term in general refers to MUPS compacted into tablets. Thus, the resulting tablets prepared by compaction of modified release coated multiparticulates or pellets are called as MUPS. It is the more recent and challenging technologies that combine the advantages of both tablets and pellet-filled capsules in one dosage form.
CLINICAL ADVANTAGE OF ESOMEPRAZOLE MUPS TABLET COMPARED TO CONVENTIONAL MODIFIED-RELEASE ESOMEPRAZOLE TABLETS AND PELLET-FILLED ESOMEPRAZOLE CAPSULES
• Ensures greater bioavailability
• Ensures uniform emptying of micro pellets from stomach into small intestine facilitates rapid dissolution of enteric coating and drug release resulting in early Tmax and Cmax (peak time and peak plasma concentration)
• Ensures lesser possibility of dose dumping
• Is a combination of fast acting and sustained action
• Ensures uniform drug release
• Once daily dosing
• Ensures lesser chance of localized irritation
• Ensures better and more uniform drug absorption
• Is better than capsules in reducing the esophageal residence time
• Minimizes fluctuation in plasma concentration of drug
PHARMACODYNAMIC ADVANTAGES:
• MUPS ensure rapid and uniform gastric emptying and subsequently uniform drug dissolution of pellets in the gastrointestinal tract due to their small size and larger surface, uniform drug absorption is facilitated which results in consistent and controlled pharmacological action.
• A further reduction in inter- and intra-subject variability in drug absorption and clinical response is facilitated since the number of pellets per MUPS dosage form is much more than a conventional pellet-filled capsule and possibility of dose dumping(in stomach) and incomplete drug release is further minimized.

INDICATION:
• Gastroesophageal reflux disease (GERD):
- Treatment of erosive reflux.
- Maintenance of healed oesophagitis to prevent recurrences.
- Symptomatic treatment of gastroesophageal reflux.
• Eradication of Helicobacter pylori in combination with appropriate antibiotics:
- At the healing of Helicobacter pylori associated duodenal ulcer.
- For the prevention of relapse of Helicobacter pylori associated peptic ulcers.
• Patients who have required a continuous NSAID treatment:
- At the healing of NSAID-associated gastric ulcers
.- For the prevention of NSAID-associated gastric and duodenal ulcers in patients at risk.
• Duodenal and Gastric Ulcer •
Zollinger-Ellison Syndrome

DOSAGE & ADMINISTRATION:
Adult from age of 18:


Indication Dose Frequency Indication Dose Frequency
Gastroesophageal Reflux Disease (GERD) Gastroesophageal Reflux Disease (GERD)
Erosive Esophagitis 40mg Once daily for Erosive Esophagitis 40mg Once daily for 4 weeks
Maintening therapy of
Maintenance therapy 4 weeks of Healing of
20mg Once daily EsophagitisErosiveEsophagitis

Stomach ulcer 20mg Once daily for H. pylori eradication
causedby NSAIDs 4to 8 weeks (Esomeprazole MUPS
tablet with Amoxicillin and 20mg Twice daily for 7 days
H. pylori eradication HeClarithromycin) aling of Erosive
(Esomeprazole MUPS 20mg Twice daily for 7days

Clarithromycin)
Zollinger 40mg to 80mg Twice daily
Ellison Syndrome

এই পাতাটি ৭৫৪ বার দেখা হয়েছে