Dogrel Plus 75mg+75mg

Tablet
Clopidogrel + Aspirin
Astra Bioparmaceuticals

Other Strength:
- Dogrel 75mg

Alternative:
- Odrel Plus 75mg+75mg
- ECOSPRIN PLUS 75mg+75mg
- Lopirel Plus 75mg+75mg
- Anclog Plus 75mg+75mg
- Replet® Plus 75mg+75mg
- Preclot AS 75mg+75mg
- Pladex-A 75mg+75mg
- Clopidol Plus 75mg+75mg
- Clocard-A 75mg+75mg
- Plagrin Plus 75mg+75mg



Dogrel Plus
Description
This is a fixed dose combination containing Clopidogrel and Aspirin. Clopidogrel is an inhibitor of platelet aggregation. Clopidogrel selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. Aspirin is also an antiplatelet agent. It acts by causing irreversible inhibition of the cyclo-oxygenase enzyme, which leads to decreased formation of thromboxane A2. Since platelets do not synthesize new enzyme, the action of Aspirin on platelet cyclo-oxygenase is permanent, lasting for the life of the platelets (7-10 days).

Indications
It is indicated for the prevention of ischemic events, myocardial infarction, stroke and cardiovascular death in patients with acute coronary syndrome.

Dosage and Administrations
The recommended dose is one tablet once daily.

Side Effects
These drugs are generally well tolerated. Side effects that have been reported include abdominal pain, dyspepsia, gastritis, diarrhea, nausea, vomiting, constipation, gastrointestinal hemorrhage, ulceration, neutropenia, rash, palpitation, syncope, drowsiness, asthenia, neuralgia, paresthesia and vertigo.

Contraindications
Hypersensitivity to Clopidogrel and/or Aspirin.Hypersensitivity to non-steroidal anti-inflammatory agents and recent history of gastrointestinal bleeding.Active pathological bleeding such as peptic ulcer or intracranial hemorrhage, or bleeding disorders like hemophilia. It is also contraindicated in patients taking oral anticoagulants.

Drug Interactions
Clopidogrel may slow the metabolism of Phenytoin, Tamoxifen, Warfarin, non-steroidal anti-inflammatory drugs (Ibuprofen, Naproxen etc.) and increase their side effects. Aspirin abolishes the effect of Enalapril in patients with severe heart failure.

Precautions
General: As with other anti-platelet agents, Clopidogrel should be used with caution in patients who may be at risk of increased bleeding from trauma, surgery, or other pathological conditions. If a patient is to undergo elective surgery and an antiplatelet effect is not desired, Clopidogrel should be discontinued 7 days prior to surgery. Hepatic or renal impairment patient: Should be avoided in patients with impaired hepatic and renal function. Aspirin causes sodium and water retention in patients with renal impairment and increases the risk of gastrointestinal bleeding. Pregnancy: Adverse effects are increased in the mother and the fetus following chronic ingestion of Aspirin. Because of possible adverse effects on the neonate and the potential for increased maternal blood loss, Aspirin and Clopidogrel should be avoided during the last three months of pregnancy. Nursing mothers: Clopidogrel and Aspirin should be avoided in nursing mothers because of the possible risk of developing Reye’s syndrome. Regular use of high doses of Aspirin could impair platelet function and produce hypothrombinemia in infants if neonatal vitamin K levels are low. Pediatric use: Safety and effectiveness of Clopidogrel and Aspirin in the pediatric population have not been established.

Overdosage
The overdose of Aspirin causes tinnitus. A single lethal dose of Aspirin in adults is not known with certainty but death may be expected at 30 gm. Gastric emptying and/or lavage is recommended as soon as possible after ingestion. No adverse events were reported after single oral administration of 600 mg of Clopidogrel in healthy volunteers. Symptoms of acute toxicity were vomiting, difficult breathing and gastrointestinal hemorrhage in all species.

Pharmaceutical Precautions
Store in a cool (below 25°C) dry place protected from light. Keep out of reach of children.

How Supplied
Dogrel Plus tablet: Each box contains 1 x10 tablets in Alu-Alu blister pack.

এই পাতাটি ১৭০ বার দেখা হয়েছে