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Diverin 10mg

Tablet
Dicycloverine Hydrochloride
ACI Pharmaceuticals

Other Strength:
- Diverin 20mg

Alternative:
- Loverin 10mg
- Cyclopan 10mg
- Colicon® 10mg
- Dirin 10mg
- Abdorin 10mg



Diverin
Description
Diverin®is a preparation of Dicycloverine Hydrochloride. It has anticholinergic and antimuscarinic effect.

Indications and Uses
Diverin®is indicated for symptomatic relief of spasmodicpain associated with intestinal colic, dysmenorrheal, functional and irritable bowel syndrome, uninary incontinence secondary to unstable detrusor muscle, infantile colic.

Dosage and Administration
Adult: 10-20mg three times dailyChildren (2-12 years): 10 mg three times dailyInfant (6months-2 years): 5-10 mg (1/2-1 teaspoonful syrup) three times daily, 15 minutes before feedsDiverin®should not be used under 6 month of age.

Side-effects
Side effects include constipation, transient bradycardia (followed by tachycardia, palpitations and arrhythmias), reduced bronchial secretions, urinary urgency and retention, dilatations of the pupils with loss of accommodation, photophobia, dry mouth, flushing and dryness of the skin.

Precautions
Diverin®should beused with caution in patient with autonomic neuropathy, hepatic or renal disease, ulcerative colitis; large doses may suppress intestinal motility to the point of producing a paralytic ileus and the use of this drug may precipitate or aggravate the serious complication of toxic megacolon, hyperthyroidism, hypertension, coronary heart disease, congestive heart failure, cardiac tachyarrythmia, hiatal hernia, known or expected prostatic hypertrophy.

Use in pregnancy & lactation
Diverin®should be used duringpregnancy only if clearly needed. No teratogenic effect was shown in animal study. Since Dicycloverine hydrochloride has been reported to be secreted in human milk. So, Diverin ̈ is contraindicated in lactating mother.

Contraindications
Diverin®in contraindicated in angle closure glaucoma, myasthenia gravis, pyloric stenosis, paralytic ileus, prostatic enlargement, obstructive uropathy, obstructive disease of gastrointestinal tract, severe ulcerative colitis and reflux esophagitis.

Drug interactions
The following agents may increase certain actions or side effects of anticholinergic drugs: amantadine, antiarrythmic agent of class 1 (e.g. quinidine), antihistamines, antipsychotic agents (e.g. phenothiazines), MAO inhibitors, narcotic analgesics (e.g. meperidine), nitrates and nitrites,
sympathomimetic agents, tricyclic antidepressants, and other drugs having
anticholinergic activity. Diverin ̈ may affect the gastrointestinal absorption of various drugs, such as digoxin, metoclopramide.

Overdosage
The signs and symptoms of overdosage are headache, nausea; vomiting; blurred vision; dilated pupils; hot, dry skin; dizziness; dryness of the mouth; difficulty in swallowing; and CNS stimulation.
Treatment should consist of gastric lavage, emetics and activated charcoal. Sedatives (e.g., Short-acting barbiturates, benzodiazepines) may be used for the management of overt signs of excitement. If indicated, an appropriate cholinergic agent may be used as an antidote.

Pharmaceutical precautions
Store in a cool and dry place. Protect from light.

Presentation
Diverin®10 mg tablet: Each tablet contains Dicycloverine Hydrochloride BP 10 mg.Diverin®20 mg tablet: Each tablet contains Dicycloverine Hydrochloride BP 20 mg.Diverin®syrup: Each 5 ml contains Dicycloverine Hydrochloride BP 10 mg.

Package Quantities
Diverin®10 mg tablet: Carton of 50 tablets in blister.
Diverin®20 mg tablet: Carton of 50 tablets in blister.
Diverin®syrup: Bottle of 50 ml.

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