Diar 500mg

Tablet
Nitazoxanide
ACI Pharmaceuticals

Other Strength:
- Diaryl 3mg

Alternative:
- NIDOZOX 500mg
- Nitazox 500mg
- Zox 500mg
- Alinix 500mg
- Proxa-A 500mg
- Adnix 500mg
- Nitalet 500mg
- Nitoxin 500mg
- Nitacure 500mg
- Xanita 500mg



Diar
Description
Diar®is an oral antidiarrheal preparation contains Nitazoxanide a synthetic antiprotozoal agent which is also effective indiarrhoea caused by Rotavirus.Nitazoxanide interfere with the pyruvate ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction which is essential to anaerobic energymetabolism.

Indications and usage
Diarrhoea caused by Giardia lamblia or Cryptosporidium parvum
Amebiasis and helminth infections

Dosage and administration
Adults and adolescents (over 12 years) : 25 ml or 500 mg tabletevery 12 hours for 3 days.
Children (4 to 11 years) : 10 ml (200 mg) every 12 hours for 3 days.
Children (1 to 3 years) : 5 ml (100 mg) every 12 hours for 3 days.It is important to take Nitazoxanide with food.

Use in pregnancy and lactation
There are no adequate and well-controlled studies in pregnant women. It is not known whether Nitazoxanide is excreted in human milk. Caution should be exercised when Nitazoxanide is administered to a nursing woman.

Side effects
Side effects may be abdominal pain, headache, nausea, anorexia, flatulence, appetite increase, enlarged salivary glands. A very serious allergic reaction is unlikely to this drug. Symptomps of allergic reaction are rash, swelling, dizziness, itching etc.

Contraindications
Hypersensitivity to Nitazoxanide or any other ingredient in the formulations. The safety and effectiveness of Nitazoxanide suspension in paediatric patients less than 1 year of age have not been studied so it should not be taken by children less than 1year of age.

Precautions
Nitazoxanide should be administered with caution to patients with hepatic, biliary and renal disease and patients with combined renal and hepatic disease.

Drug interactions
Nitazoxanide is highly bound to plasma protein. Therefore caution should be used when administering Nitazoxanide concurrently with other highly plasma protein-bound drugs with narrow therapeutic index, as competition for binding sites mayoccur (e.g., warfarin).

Direction for reconstitution of suspension
Shake the bottle well before mixing the water. To prepare 60 ml suspension add 45 ml (9 tea spoonfuls) and for 30 ml suspension add 22.5 ml (4.5 teaspoonfuls) boiled and cooled water in two portions and shake till powder is completely mixed with water. Keep the prepared suspension in cool place. Use the supplied spoon for water measurement.

Direction for use
Shake the bottle vigorously before each use. Keep the bottle tightly closed. The reconstituted suspension should be used within 7 days after reconstitution.

Pharmaceutical precautions
Store in a cool dry place. Protect from light & moisture.

Presentation
Diar®500 mg tablet : Yellow colored, oval shaped film coated tablet. Each tabletcontains Nitazoxanide INN 500 mg.Diar®powder for suspension: A pink colored, tuttifrutti flavored powder forsuspension. When reconstituted each 5 ml contains Nitazoxanide INN 100 mg.

Package quantities
Diar®powder for suspension : Bottle of 60 ml and 30 ml.Diar®500 mg tablet : Carton of 10 tablets in Alu PVC blister.

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