Cab 5mg

Tablet
Amlodipine
ACI Pharmaceuticals

Other Strength:
- Cabolac 0.5mg
- Caberol 0.5mg
- Cabergol 0.5mg
- Abecab 5mg+20mg
- Abecab 5mg+40mg
- Caber 0.5mg
- Cilocab 10mg
- Cilocab 5mg
- Tenocab 5mg+25mg
- Tenocab 5mg+50mg
- Noscab 5%w/w
- Scabex 5%w/w
- Cabolin 0.5mg

Alternative:
- AMLOPIN 5mg
- Amlotab 5mg
- Xelcard 5mg
- Amlovas 5mg
- Calvasc 5mg
- Amdin 5mg
- Lodipin 5mg
- Ampress 5mg
- Nopidin 5mg



Cab
Presentation
Cab5mg tablet: Each tablet contains Amlodipine 5mgas Besilate BP.

Description
Cab(Amlodipine) is a calcium channel blocker of dihydropyridine group having long duration of action and used for the treatment of hypertension and angina pectoris. Cabinhibits the transmembrane influx of calcium ions cardiac and smooth muscle. The mechanism of antihypertensive action of Cabis due to a direct relaxant effect on vascular smooth muscle. In angina, Cabreduces total ischaemic burden by dilatingperipheral arterioles and probably the main coronary arteries and coronary arteries. After oral administration of therapcutic doses, Cabis well absorbed with peak blood levels between 6-12 hours post dose. The terminal plasma elimination half-life is about 35-50 hours and is consistent with once-daily administration. Steady-state plasma levels are reached after 7-8 days.

Uses
Hypertension: Cabisindicated for the first line treatment of hypertension and can be used as sole agent to control blood pressure in the majority of patients. Patients not adequately controlled on a single antihypertensive agent may benefit from the addition of Cabwhich has been used in combination with a thiazide diuretic, beta-adrenoceptor blocking agent or an angiotensin converting inhibitor.Chronic stable angina:Cabisindicated for the first line therapy of stable angina. It may be used in combination with other antianginal drugs.Vasospastic angina:Cabisindicated where clinical presentation suggests a possible vasospastic angina.Cabmay be used as monotherapy, or in combination with other antianginal drugs in patients with angina that is refractory to nitrates and / or adequate doses of beta-adrenoceptor blocking agents.

Dosage and administration
For both hypertension and angina, the recommended initial dose is 5mg Caborally once daily which may be increased to a maximum dose of 10mgdepending on the patient’sresponse. Small, fragile or elderly individuals or patientswith hepatic insufficiency may be started on 2.5mg once daily dose and this dose may be used when adding Cabto other antihypertensivetherapy.The recommended dose for chronic stable or vasospastic angina is 5-10mg, with the lower dosesuggested in the elderly and in patients with hepatic insufficiency.

Paediatric UseSince there is no clinical experience in patients of less than 18 years, use in children is not currently recommended.

Contra-indications, warnings etc.
Contra-indications: Cabis contra-indicated in patients with a known hypersensitivity to dihydropyridines.

Warnings and Precautions:
Use in pregnancy and lactation:There is no clinical experience with Cabin pregnancy or lactation. Accordingly, Cabshouldnot be administered during pregnancy or lactation or to women of child-bearing potential unless effective contraception is used.Driving / use of machinery:Clinical experience with Cabindicates that is unlikely to impair a patient’s ability to driver or use machinery.Drug Interactions:Cabhas been safely administered with thiazide diuretics, beta-adrenoceptor blocking drugs, angiotensin converting enzyme inhibitors, trinitrate, non-steroidal anti-inflammatory drugs, antibiotics and oral hypoglycaemic agents.Co-administration of Cabwith digoxin did not change serum digoxin level or digoxin renal clearance in normal volunteers. Co-administration of cimetidine did not alter the pharmacokinetics of amlodipine. In healthy volunteers, co-administration of Cabdid not significantly alter the effect of warfarin onprothrombin time.Food-Cabcan be administered regardless of food.

Adverse effects:
Cabis well tolerated. In placebocontrolled clinical trials involving patients with hypertension or angina, the most commonly observed side effects were headache, oedema, fatigue, skin erythema, nausea, flushing and dizziness. There is evidence that these effects are more common in patients treated with doses greater than 10mg daily.

Overdosage:
Thereis no well documented experience with Caboverdosage. Since Amlodipine absorption is slow, gastric lavage may be worthwhile in some cases. Gross overdosage could result in excessive peripheral vasodilation with subsequent marked and probably prolonged systemic hypotension. Clinicallysignificant hypotension due to Caboverdosage calls for active cardiovascular support including monitoring of cardiac and respiratory function, evaluation of extremities and attention to circulating fluid volume and urine output.A vasoconstrictor agent may be helpful in restoring vascular tone and blood pressure provided that there is no contraindication to its use. Since amlodipine is highly protein-bound, dialysis is unlikely to be of benefit.

Pharmaceutical precautions
Store below 30C.

Package quantities
Cab5mg tablet: Cartons of 50 tablets in blister.

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