Axetil 500mg

Tablet
Cefuroxime Axetil
Alco Pharma

Other Strength:
- Axetil 250mg
- Axetil 125mg

Alternative:
- Cefotil® 500mg
- Furotil 500mg
- Cefobac 500mg
- Cerox-A Tablet 500mg
- Xitil 500mg
- Roximax 500mg
- Axicef 500mg
- Axefur 500mg
- Axim 500mg
- C-2 500mg
- Benkill 500mg
- Famicef 500mg
- Furocef 500mg



Axetil
Description:
Axetil is a preparation of Cefuroxime. It is a semi synthetic, broad spectrumCephalosporin antibiotic for oral and parenteral administration; which is active against a wide range of gram-positive and gram-negative organisms including many β-lactamase producing strains.

Composition:
Axetil 125: Each film coated tablet contains Cefuroxime Axetil BP equivalent to Cefuroxime 125 mg.

Axetil 250: Each film coated tablet contains Cefuroxime Axetil BP equivalent to Cefuroxime 250 mg.

Axetil 500: Each film coated tablet contains Cefuroxime Axetil BP equivalent to Cefuroxime 500 mg.

Axetil dry powder for suspension: After reconstitution according to direction, each 5 ml suspension contains Cefuroxime Axetil BP equivalent to Cefuroxime 125 mg.

Indication/Use:
Axetil is indicated for:

Upper respiratory tract infections including otitis media, sinusitis, tonsillitis and pharyngitis

Lower respiratory tract infections including acute and chronic bronchitis and pneumonia

Genito-urinary tract infections including pyelonephritis, cystitis and urethritis, gonorrhea, acute uncomplicated gonococcal urethritis and cervicitis

Skin and soft tissue infections including furunculosis, pyoderma and impetigo

Gonorrhea including acute uncomplicated gonococcal urethritis and cervicitis

Early lyme disease including erythema & marginatum

Dosage Guideline:

Infections


Dosage


Duration(Days)

Tablet: Adolescents and adults (13 years of age and above)







Pharyngitis, Tonsillitis


250 mg b.i.d


5-10

Acute bacterial maxillary sinusitis


250 mg b.i.d


10

Acute bacterial exacerbation of chronic bronchitis


250-500 mg b.i.d


10

Secondary bacterial infections of acute bronchitis


250-500 mg b.i.d


5-10

Uncomplicated skin and skin-structure infections
250-500 mg b.i.d
10
Uncomplicated urinary tract infections
125-250 mg b.i.d
7-10
Uncomplicated gonorrhea
1000 mg once
1
Lyme disease
500 mg b.i.d
20
Tablet: Pediatric Patients up to 12 years (Who can swallow tablets)
Pharyngitis, Tonsillitis
125 mg b.i.d
5-10
Acute otitis media
250 mg b.i.d
10
Acute bacterial maxillary sinusitis
250 mg b.i.d
10
Suspension: Paediatric patients (3 months – 12 years)
Pharyngitis, Tonsillitis
20 mg/kg/day in 2 divided doses
5-10
Acute otitis media
30 mg/kg/day in 2 divided doses
10
Acute bacterial maxillary sinusitis
30 mg/kg/day in 2divided doses
10

Side Effects:
Generally Cefuroxime is well tolerated; however a few side effects like nausea, vomiting, diarrhea, abdominal discomfort, or pain may occur. As with other broad-spectrum antibiotics prolonged administration of Cefuroxime may result in overgrowth of non susceptible microorganisms.

Contraindication:
Cefuroxime is contraindicated in patients with known hypersensitivity to Cephalosporins& patients with pseudomembraneous colitis.

Drug Interaction:
Drug interaction is common with other antibiotics. Cefuroxime may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined estrogen /progesterone oral contraceptives.

Use in Pregnancy & Lactation:
While all antibiotics should be avoided in the first trimester if possible, Cefuroxime has been safely used in later pregnancy to treat urinary and other infections. Cefuroxime is excreted in human milk, and consequently caution should be exercised when Cefuroxime is administered to a nursing mother.

Over Dose:
Over dosage of Cefuroxime can cause cerebral irritation leading to convulsions. Serum levels of Cefuroxime can be reduced by haemodialysis and peritoneal dialysis.

Precaution:
As with other antibiotics, prolonged use of Cefuroxime may result in the over growth of non-susceptible organisms (e. g. Candida, Enterococci, Clostridium difficile), which may require interruption of treatment. Pseudomonous colitis has been reported with the use of broad-spectrum antibiotics; therefore, it is important to consider its diagnosis in patients who develop serious diarrhea during or after antibiotic use.

Therapeutic Class:
Anti-Infective

Dosage Form:
Tablet and PFS

Storage:
Store in a cool dry place. Protect from light.




এই পাতাটি ১৬৪ বার দেখা হয়েছে