Ampress Plus 5mg+50mg

Tablet
Amlodipine + Atenolol
BENHAM pharmaceuticals

Other Strength:
- Ampress 5mg

Alternative:
- Camlodin Plus 5mg+50mg
- Tenocab 5mg+50mg
- Calbeta 5mg+50mg
- Amdin Plus 5mg+50mg
- Lodicard 5mg+50mg
- Amloten 5mg+50mg



Ampress Plus
Composition:
Ampress Plus: Each film coated tablet contains Amlodipine besylate BP equivalent to Amlodipine 5mg + Atenolol BP 50mg.

Description:
Amlodipine is a dihydropyridine calcium antagonist that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. Amlodipine is a peripheral vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. Amlodipine reduces tone, decreases coronary vasoreactivity and lowers cardiac demand by reducing after load. Atenolol is a cardio selective beta-blocker. Atenolol causes a reduction in blood pressure by lowering cardiac output, decreasing the plasma renin activity and sympathetic outflow from CNS. Atenolol also causes a reduction in myocardial oxygen demand by virtue of its negative inotropic and negative chronotropic effects.

Indications:
Patients with essential hypertension, patients with angina pectoris & hypertension as co-existing diseases, in post MI patients in patients with refractory angina pectoris where nitrate therapy has failed.

Dosage & Administration:
The therapy is initiated with a single dose of Amlodipine 5mg plus Atenolol 50mg depending upon the therapeutic response. titration of the dosage is recommended. In elderly patients, it is advisable to initiate the therapy with 1/2 tablet to fixed dose combination of Amlodipine & Atenolol i.e. 2.5mg of Amlodipine & 25mg Atenolol.

Contraindications:
Hypersensitivity to either component, sinus bradycardia, second and third degrees of heart block, cardiogenic shock, hypotension, congestive heart failure, poor left ventricular function.

Precautions:
The combination should be used with caution in patients with airway obstruction, renal impairment, hepatic impairment.

Side-effects:
The combination of Amlodipine and Atenolol is well tolerated. Overall side effects include fatigue, headache, edema, nausea, drowsiness, anxiety and depression.

Use in pregnancy and lactation:
The combination should be used during pregnancy only if the expected benefit outweighs the potential fetal risk. The combination should not be used by nursing mothers. If its use is considered necessary, breast-feeding should be stopped.

Drug interactions:
Disopyramide: Atenolol reduces the clearance of disopyramide by 20 %. Additive negative inotropic effects on the heart may be produced. Ampicillin:At doses of 1 gm and above may reduce Atenolol levels. Oral antidiabetics and insulin: Beta-blockers may decrease tissue sensitivity to insulin and inhibit insulin secretion e.g. in response to oral antidiabetics.



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