Aloran 5mg

Tablet
Desloratadine
Alco Pharma

Other Strength:

Alternative:
- Momento 5mg
- ORINEX 5mg
- Neocilor 5mg
- Deslorin 5mg
- Destin 5mg
- Desolet 5mg
- Benlor 5mg
- Sedno 5mg



Aloran
Description:
Aloran (Desloratadine) is a potent, rapidly effective, long-acting, non-sedative antihistamine withselective H1 receptor histamine antagonist activity. It is an orally administered drug.

Composition:
Aloran Tablets: Each coated tablet contains Desloratadine INN 5 mg

Indication/Use:
Aloran is used for the relief of nasal and non-nasal symptoms of allergic rhinitis (seasonal and perennial) and management of chronic idiopathic urticaria. Desloratadine is a major active metabolite of Loratadine. It is a long-lasting, non-sedating, selective peripheral histamine H1-receptor antagonist. It acts by inhibiting the release of pro-inflammatory mediators from human mast cells/basophils.

Dosage Guideline:
Adult and adolescent over 12 years: In adult and adolescent of 12 years of age and over therecommended dose of Aloran tablets is 5 mg once daily. In patients with liver or renal impairment, a starting dose of one 5 mg tablet every other day is recommended based on pharmacokinetic data.

Children: 2-5 years 1.25 mg daily and 6-11 years 2.5 mg daily.

Side Effects:
CNS: Drowsiness (rare), EENT: pharyngitis,
GI: dry mouth, Misc.: allergic reaction including anaphylaxis.
Desloratadine was well tolerated during clinical trials involving more than2000 patients; undesirable effects were reported in 4% of patients in excess of those treated with placebo. Headache (6%), dry mouth (3%) and fatigue (3%) were the most common adverse effects. No excess incidence of somnolence/sedation was reported. No significant ECG or other adverse cardiovascular effects have been reported with Desloratadine. No adverse effect on cardiovascular function was observed in healthy volunteers with Desloratadine in doses of up to 20 mg daily for 14 days or at 45 mg daily for 10 days.

Contraindication:
Aloran is contra-indicated in patients who are hyper-sensitive to thismedication or to any of its ingredients, or to Loratadine.

Drug Interaction:
No relevant drug interactions were observed in clinical trials in whicherythromycin or Ketoconazole were given together with Desloratadine. However, as the enzyme responsible for Desloratadine metabolism has not been clearly identified, the potential for interactions with other drugs cannot be excluded. Management of over dosing: In the event of over dose, consider standard measures to removeany unabsorbed drug. Symptomatic and supportive treatment is recommended. Desloratadine and 3-hydroxydesloratadine are not eliminated by hemodialysis.
MAO inhibitors may intensify and prolong effects of anti-histamines. Additive CNSdepression may occur with other CNS depressants including alcohol, anti-depressants, opioids, and sedative/hypnotics.

Use in Pregnancy & Lactation:
Pregnancy: Aloranshould not be used in pregnancy unless the potential benefits outweigh therisks. Clinical data on pregnancy outcome in women exposed to Desloratadine are not available although no teratogenic and mutagenic effects were observed in animal studies. Pregnancy outcome data after exposure to Loratadine is also too limited to allow an assessment of any teratogenic risk.
Lactation: As Desloratadine is excreted into breast milk it is not recommended for use inbreastfeeding women.

Over Dose:
No clinically relevant adverse events were reported. Inthe event of overdose, consider standard measures toremove anyunabsorbed drug. Symptomatic and supportive treatment is recommended. Desloratadineand 3-hydroxydesloratadine are not eliminated byhemodialysis.

Precaution:
Desloratadine should be used with caution in patients with severe renal impairment.

Therapeutic Class:
Antihistamine

Dosage Form:
Tablet

Storage:
Store in a cool and dry place, protected from light.



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