ঔষধের বিস্তারিত বা বিকল্প ঔষধ জানতে ঔষধের নাম দিয়ে সার্চ দিন। যেমন- Napa বা Alatrol বা Amodis
Terazosin Hydrochloride
Indications Terazosin Hydrochloride single therapy is used to relieve for signs and symptoms of benign prostatic hyperplasia (BPH), for the treatment of hypertension
Pharmacology Terazosin is an α1-adrenoceptor antagonist which blocks peripheral postsynaptic receptors resulting to decreased arterial tone. It relaxes smooth muscle of the bladder neck causing a reduction of bladder outlet obstruction. In general, α1-adrenergic receptors mediate contraction and hypertrophic growth of smooth muscle cells. α1-Receptors are 7-transmembrane domain receptors coupled to G proteins, Gq/11. Three α1-receptor subtypes, which share approximately 75% homology in their transmembrane domains, have been identified: α1A (chromosome 8), α1B (chromosome 5), and α1D (chromosome 20). Terazosin is the first α1-receptor antagonist to demonstrate selectivity for the α1A-receptor. All three receptor subtypes appear to be involved in maintaining vascular tone. The α1A-receptor maintains basal vascular tone while the α1B-receptor mediates the vasocontrictory effects of exogenous α1-agonists. Activation of α1-receptors activates Gq-proteins, which results in intracellular stimulation of phospholipases C, A2, and D. This results in mobilization of Ca2+ from intracellular stores, activation of mitogen-activated kinase and PI3 kinase pathways and subsequent vasoconstriction. Terozosin produces its pharmacological effects by inhibiting α1A-receptor activation. Inhibition of these receptors in the vasculature and prostate results in muscle relaxation, decreased blood pressure and improved urinary outflow in symptomatic benign prostatic hyperplasia.
Dosage & Administration Benign Prostatic Hyperplasia: Initial dose: 1 mg at bedtime is starting dose of all patients and this dose should not be exceeded. Subsequent dose: The dose slowly increases to achieve the desired response. The usual recommended dose range is 5-10 mg administered once a day. Hypertension: Initial dose: 1 mg at bedtime is starting dose of all patients and this dose should not be exceeded. Subsequent dose: The dose slowly increases to achieve the desired response. The usual recommended dose range is 2-10 mg administered once a day.
Interaction In patients receiving Terazosin plus ACE inhibitors or diuretics the proportion reporting dizziness or related side effects was greater than in the total population of Terazosin treated patients from clinical trials. Terazosin has been given without interaction with analgesics/ anti-inflammatory, cardiac glycosides, hypoglycemic, antiarrhythmic, anxiolytics/ sedatives, antibacterial, hormones/ steroids and drugs used for gout.
Contraindications Terazosin is contraindicated in patients known to be hypersensitive to Terazosin or its analogues.
Side Effects Postural hypertension is more commonly reported side effect. Dizziness, lack of energy, peripheral oedema; urinary frequency and priapism reported.
Pregnancy & Lactation The safety of Terazosin during pregnancy has not been established so Terazosin is not recommended during pregnancy unless the potential benefit justifies the potential risk to moher and fetus. It is not known whether Terazosin is excreted in breast milk. Because many drugs are excreted in breast milk, caution should be exercised when Terazosn is administered to a nursing mother.
Precautions & Warnings First dose may cause hypotension (within 30-90 minutes). Therefore should be taken on retiring to bed. Caution should be observed when Terazosin is administered with other antihypertensive agents; avoid the possibility of significant hypotension. When adding Terazosin to a diuretic or other antihypertensive agent, dosage reduction and retitration may be necessary. The patients should be cautioned to avoid situation such as driving and hazardous tasks where injury could result due to syncope after initiation of Terazosin therapy.
Overdose Effects Acute overdose may lead to acute hypotension, cardiovascular support is of first importance. Restoration of blood pressure and normalization of heart rate may be accomplished by keeping the patient in a supine position. At the same time expansion of plasma volume and nor-adrenergic vasopressor may also be needed.
Storage Conditions Store between 20-25° C. Protect from light and moisture.
