Desoximetasone

Indications
Desoximetasone Emollient Cream indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-inflammatory and pruritic manifestations of corticosteroid

Therapeutic Class
Other Topical corticosteroids

Pharmacology
The precise mechanism of the antiinflammatory activity of topical steroids in the treatment of steroid-responsive dermatoses, in general, is uncertain. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. This is achieved first by the drug binding to the glucocorticoid receptors which then translocates into the nucleus and binds to DNA causing various activations and repressions of genes. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.

Dosage & Administration
Apply a thin film of Desoximetasone Emollient Cream to the affected skin areas twice daily. Rub in gently

Contraindications
Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.

Pregnancy & Lactation
Pregnancy Category C

Overdose Effects
Topically applied corticostero systemic effects