Z-Antacid 250mg+400mg

Tablet
Aluminium Hydroxide + Magnesium Hydroxide
Ziska Pharmaceuticals Limited

Other Strength:

Alternative:
- OXECONE 250mg+400mg
- Entacyd® 250mg+400mg
- Antacid 250mg+400mg
- Duomeal 250mg+400mg



Z-Antacid

Composition
Each tablet contains-

Dried Aluminium Hydroxide Gel BP (Al2O3 47%, minimum): 250 mg
Magnesium Hydroxide BP: 400 mg

Each 5 ml contains-

Aluminium Oxide (Equivalent amount of Aluminium Hydroxide Gel USP): 175 mg
Magnesium Hydroxide (Equivalent amount of Magnesium Hydroxide Paste USP): 225 mg


Indications
Aluminium Hydroxide and Magnesium Hydroxide is indicated for Hyperacidity, peptic ulcer, gastritis, heartburn, sour stomach & dyspepsia.


Therapeutic Class
Antacids


Pharmacology
This drug is well-balanced combination of essential non-systemic antacids which excel in efficacy and palatability. These are dependable antacid preparations without acid rebound, constipating or cathertic effects. Both the preparations provide symptomatic relief of hyperacidity associated with heartburn, acid ingestion or sour stomach.

Aluminium hydroxide gel, a slow acting antacid and an adsorbent with prolonged effect, has high neutralizing power. Magnesium Hydroxide possesses a slow but sustained acid neutralizing property. Antacids of both tablet and suspension possess adsorbent property. They form a protecting coating over the ulcer surface facilitating its healing; thus protecting the sensitive mucosa of stomach and duodenum from further irritation.


Dosage & Administration
Tablet: Two tablets 1-3 hours after meal and at bed time or as directed by the physician.

Suspension: 2 tea spoonful 1-3 hours after meal and at bed time or as directed by the physician.


Interaction
This drug inhibits the absorption of following drugs: Azithromycin, cefpodoxime, ciprofloxacin, isoniazid, rifampicin, norfloxacin, ofloxacin, pivampicillin, tetracyclines, Gabapentin and phenytoin, Itraconazole, ketoconazole, Chloroquine, hydroxychloroquine and Phenothiazines.


Contraindications
This is contraindicated in hypophosphataemia. It is also contraindicated in alkalosis and hypermagnesaemia where abdominal distention may be due to partial or complete intestinal obstruction.


Side Effects
Long term use of any antacid results in alkaluria, which may predispose to nephrolithiasis by forming precipitation of calcium phosphate.


Pregnancy & Lactation
It is advised to avoid antacid preparations in the first trimester of pregnancy.


Precautions & Warnings
Antacids reduce the absorption of tetracycline when given concomitantly. These should not be used concomitantly


Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.


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