X-Cite 50mg

Tablet
Sildenafil Citrate
Alco Pharma

Other Strength:
- X-Cite 100mg

Alternative:
- Enegra 50mg
- Silagra 50mg
- Vigorex 50mg
- Enigma 50mg
- Adegra 50mg
- Viamax 50mg
- Veagra 50mg
- Starfil 50mg



X-Cite
Description:
Sildenafil is a selective, reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). It works by helping to relax the blood vessels of penis, allowing blood to flow into penis.

Composition:
X-cite 50 tablet: Each film coated tablet contains Sildenafil citrate INN equivalent to Sildenafil 50 mg.
X-cite 100 tablet: Each film coated tablet contains Sildenafil citrate INN equivalent to Sildenafil 100 mg.

Pharmacology:
When sexual stimulation causes the local release of nitric oxide; inhibition of PDE5 by Sildenafil produces increased levels of cGMP in the corpus cavernosum. This results in smooth muscle relaxation and inflow of blood into the penile tissues, thereby producing an erection. Sildenafil has no effect in the absence of sexual stimulation.

Indication/Use:
Sildenafil is indicated for the treatment of erectile dysfunction and pulmonary arterial hypertension.

Dosage Guideline:
Erectile Dysfunction:
For most patients, the recommended dose is 50 mg taken, as needed, approximately 1 hour before sexual activity. However, Sildenafil may be taken anywhere from 0.5 hours to 4 hour before sexual activity. Based on effectiveness and toleration, the dose may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg. The maximum recommended dosing frequency is once per day.

Pulmonary arterial hypertension:

The recommended dose of Sildenafil is 20 mg three times a day and should be taken approximately 4-6 hours apart with or without food.

Use in children and adolescents: Sildenafil is not indicated for individuals below 18 years of age.
Use in elderly patients: Dosage adjustment is not required in elderly patients.
Use in patients with impaired renal function: Since Sildenafil clearance is reduced in patients with severe renal impairment (creatinine clearance < 30 ml/min) 25 mg dose should be considered. Based on efficacy and toleration, the dose may be increased to 50 mg and 100 mg.
Use in patients with impaired hepatic function: Since Sildenafil clearance is reduced in patients with hepatic impairment (e.g. cirrhosis) a 25 mg dose should be considered. Based on efficacy and toleration, the dose may be increased to 50 mg or 100 mg.

Side Effects:
The most commonly reported adverse reactions in clinical studies among Sildenafil treated patients were headache, flushing, dyspepsia, nasal congestion, dizziness and visual color distortion.

Contraindication:
Consistent with its known effects on the nitric oxide/cGMP pathway, Sildenafil was shown to potentiate the hypotensive effects of nitrates and its administration to patients who are using organic nitrates, either regularly and/or intermittently, in any form is therefore contraindicated.
Sildenafil is contraindicated in patients with a known hypersensitivity to any component of the tablet.

Drug Interaction:
Hypotensive effects can be enhanced if Sildenafil is co-administered with Alpha blockers (avoid alpha blockers for 4 hours after Sildenafil), Amlodipine, Nicorandil, Nitrates (avoid concomitant use). Co-administration of Sildenafil with Atazanavir increases the side effects. Plasma concentration of Sildenafil is increased if it is co-administered with Bosentan, Cimetidine, Clarithromycin, Erythromycin, Fosamprenavir, Grapefruit Juice, Indinavir, Itraconazole, Ketoconazole, Nelfinavir, Ritonavir, Telithromycin. Etravirine reduces plasma concentration of Sildenafil.

Use in Pregnancy & Lactation:
Pregnancy category B. Sildenafil is not indicated for use in newborns, children, or women.

Over Dose:
In studies with healthy volunteers of single doses up to 800 mg, adverse events were similar to those seen at lower doses but incidence rates and severities were increased. In cases of overdose, standard supportive measures should be adopted as required. Renal dialysis is not expected to accelerate clearance as Sildenafil is highly bound to plasma proteins and it is not eliminated in the urine.

Precaution:
Sildenafil should be used with caution in cardiovascular disease, left ventricular outflow obstruction, anatomical deformation of the penis (e.g. angulation, cavernosal fibrosis, peyronie's disease) and in those with a predisposition to priapism (e.g. in sickle-cell disease, multiple myeloma, or leukaemia). Concomitant treatment with a phosphodiesterase type-5 inhibitor and an alpha-blocker can increase the risk of postural hypotension-initiate treatment with a phosphodiesterase type-5 inhibitor (at a low dose) only once the patient is stable on the alpha blocker.

Therapeutic Class:
Anti-Erectile dysfunction agent

Dosage Form:
Tablet

Storage:
Store in a cool and dry place. Protect from light and moisture. Keep the medicine out of children's reach.


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