Prosan 50mg

Tablet
Losartan Potassium
Beximco Pharmaceuticals Ltd

Other Strength:
- Prosan HZ 50mg+12.5mg

Alternative:
- LOSART 50mg
- Losacor 50mg
- Losatan 50mg
- Rosatan 50mg
- Losamax 50mg
- Araten 50mg
- Losa 50mg
- Osartan 50mg
- Loril 50mg
- Losapress 50mg
- Angilock 50mg



Prosan
1. What Prosan® is and what it is used for?
Prosan® (Losartan Potassium) is an angiotensin-II receptor (type AT1) antagonist. Angiotensin-II is a potent vasoconstrictor, the primary vasoactive hormone of the renin-angiotensin system and an important component in the pathophysiology of hypertension. Losartan and its principal active metabolite block the vasoconstrictor and aldosterone secreting effects of angiotensin-II by selectively blocking the binding of angiotensin-II to the AT1 receptor found in many tissues. It is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents.

2. Before you take Prosan®
Contraindication
Losartan Potassium is contraindicated in patients who are hypersensitive to the active ingredient or any component of the drug.

Overdosage
Limited data are available regarding overdosage in human. The most likely manifestation of overdosage would be hypotension and tachycardia; bradycardia could occur from parasympathetic (vagal) stimulation. Supportive treatment should include repletion of the intravascular volume.

3. How to take Prosan®?
The usual starting dose is 50 mg once daily, with 25 mg used in patients with possible depletion of intravascular volume (e.g., patients treated with diuretics) and patients with a history of hepatic impairment. It can be administered once or twice daily with total daily doses ranging from 25 mg to 100 mg.

4. Possible side effects
In clinical trials, dizziness was the only side effect reported that occurred with an incidence greater than placebo in 1% patients treated with Losartan. Rarely, rash was reported, although the incidence in controlled clinical trials was less than placebo. Angioedema, involving swelling of the face, lips and/or tongue, has been reported rarely in patients treated with Losartan. The incidence of cough is similar to placebo and significantly lower than that observed with ACE inhibitors.

Use in Special Population
Children: There are no data on the safety or efficacy of Prosan® in children.
Pregnant women: Prosan must be discontinued as soon as possible when pregnancy is detected. It should not be prescribed during lactation, as there is no information in human on the passage ofLosartan into breast milk.
Elderly: In elderly patients up to 75 years of age, no dosage adjustment is necessary.

5. How to store Prosan®?
Store in a dry place, at temperature between 15° C and 30 0C, away from light.

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