Phydox 400mg

Tablet
Doxophylline
BENHAM pharmaceuticals

Other Strength:
- Phydox 200mg

Alternative:
- Fixolin 400mg
- Dophylin 400mg
- Brezofil 400mg
- Flindof™ 400mg
- Clarence 400mg
- Doxofyl 400mg
- Doxofyl SR 400mg
- Doximar 400mg
- Doxolator 400mg
- Pulmodox 400mg
- Docopa 400mg
- Pulmino 400mg



Phydox
Presentation:
Phydox 200 tablet: Each film coated tablet contains Doxophylline INN 200mg.
Phydox 400 tablet: Each film coated tablet contains Doxophylline INN 400mg.

Descriptions:
Doxophylline, a new generation xanthine belonging to a new class of drug referred to as Novofylline, which is chemically 1,3- dimethyl-3,7-dihydro-purine-2,6-dione. Its molecular formula is C11H14N4O4 and its molecular weight is 266.253 g/mol. Doxophylline is a new creation long lasting oral methylxanthine extract. Methylxanthines are from the family of phosphodiesterase inhibitors. Correspondingly, its system of activity is associated to the reticence of phosphodiesterase action, initiating in bronchodilating actions. It has a bronchodilator effect which reduces rate of breathlessness in patients suffering from asthma. It helps relax the muscles in the bronchi and bronchioles, thus causing dilatation of the air passages and helping patients to breathe easily. The drug also possesses antitussive properties which help to control the cough linked with lung disorders.

Indications:
Doxophylline is mostly administered for maintenance treatment in subjects experiencing COPD (Chronic Obstructive Pulmonary Disease) and bronchial asthma. Doxophylline is not designed for use as an emergency treatment during an asthma attack.

Dosage & Administration:
Adults: 400 mg tablet daily in the evening .On the basis of clinical response the dose may be increased to 1 tablet three times daily according to prescribing physician.
Elderly: The dosage may be decreased according to medical prescription in the very elderly patients, 200 mg tablet in the evening two or three times daily according to prescribing physician.

Maximum Daily dose:1200mg .
Children(above 6 years of age): 6mg/kg body weight twice daily. Doxophylline may be taken with or without food.

Side Effects:
After xanthine administration, nausea, vomiting, epigastric pain, cephalalgia, irritability, insomnia, tachycardia, extrasystole, tachypnea and occasionally, hyperglycemia and albuminuria, may occur. If a potential oral overdose is established, the patient may present with severe arrhythmias and seizure; these symptoms could be the first sign of an intoxication. Adverse reactions may cause the withdrawal from treatment; a lower dose rechallenge may start only after the advice of a physician.

Precautions: Use with caution in patients with hypoxemia, hyperthyroidism, liver disease, renal disease, in those with history of peptic ulcer and in elderly. Frequently, patients with Congestive Heart Failure (CHF) have markedly prolonged drug serum levels following discontinuation of Doxofylline.

Contraindications: This is contraindicated for individuals who have shown hypersensitivity to Doxophylline and its components. It is also contraindicated in patients with acute myocardial infarction, hypotension, and in lactating women.

Use in Pregnancy & Lactation:
Animal reproduction studies indicate that Doxophylline does not cause fetal harm when administered to pregnant animals nor can affect reproduction capacity. However, since there is limited experience in human during pregnancy, xanthines should be given to a pregnant woman only if clearly needed.

Drug Interaction:
Doxophylline should not be administered together with other xanthine derivatives. Toxic synergism with ephedrine has been documented for xanthines. Like other xanthines, concomitant therapy with erythromycin. troleandomycin, lincomycin, clindamycin, allopurinol, cimetidine, ranitidine, propranolol and anti-flu vaccine may decrease the hepatic clearance of xanthines causing an increase in blood levels. No evidence of a relationship between Doxophylline serum concentrations and toxic events have been reported.

Overdose: Although no major arrhythmias have been documented with Doxophylline , the occurrence of major cardiac rhythm disturbances cannot be excluded in case of overdosage of xanthine compounds. If a potential oral overdose is established, the patient may present with seizures; this symptom could be the first sign of intoxication. Adverse reactions may cause withdrawal from treatment.

Storage:
- Store at room temperature (not exceeding 25°C).
- Store in cool and dry place, protected from light.
Doxophylline should be used only on prescription of specialist physician.



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