Limitrol 12.5mg+5mg

Tablet
Amitriptyline + Chlordiazepoxide
Ziska Pharmaceuticals Limited

Other Strength:

Alternative:
- Limbix 12.5mg+5mg



Limitrol
Presentation
Each film coated tablet contains Chlordiazepoxide HCl BP equivalent to Chlordiazepoxide 5 mg & Amitriptyline HCl BP equivalent to Amitriptyline 12.5 mg.

Description
Limitrol Combines Amitriptyline, a tricyclic antidepressant and Chlordiazepoxide, an anxiolytic. Amitriptyline inhibits the reuptake of norepinephrine and serotonin in brain. This interference with the reuptake is responsible for antidepressant activity of Amitriptyline. Chlordiazepoxide works by enhancing GABA-mediated chloride influx through GABA receptor channels, causing membrane hyperpolarization. The net neuro-inhibitory effects result in the observed sedative and anxiolytic effect.

Indications
This combination is indicated for the treatment of patients with moderate to severe depression associated with moderate to severe anxiety. Symptoms likely to respond in the first week of treatment include: insomnia, feelings of guilt or worthlessness, agitation, psychic and somatic anxiety, suicidal ideation and anorexia.

Dosage & Administration
Optimum dosage varies with the severity of the symptoms and the response of the individual patient. When a satisfactory response is obtained, dosage should be reduced to the smallest amount needed to maintain the remission. The larger portion of the total daily dose may be taken at bedtime. In some patients, a single dose at bedtime may be sufficient. Initial dosage of 3 or 4 tablets daily in divided doses is satisfactory.

Side Effects
Many symptoms common to the depressive state, such as anorexia, fatigue, weakness, restlessness and lethargy, have been reported as side effects of treatment with this combination.

Precautions
Use with caution in patients with a history of seizures. Close supervision is required when it is given to hyperthyroid patients or those on thyroid medication. The usual precautions should be observed when treating patients with impaired renal or hepatic function. All pediatric patients being treated with antidepressants for any indication should be monitored appropriately and observed closely for clinical worsening, suicidality and unusual changes in behavior.

Contraindications
This combination is contraindicated in patients with hypersensitivity to either benzodiazepines or tricyclic antidepressants. It should not be given concomitantly with a monoamine oxidase inhibitor.

Commercial Packaging
Each box contains 3 x 10’s tablets in blister pack.

Drug Interaction
Because of its Amitriptyline component, this combination may block the antihypertensive action of guanethidine or compounds with a similar mechanism of action.

Overdose
Critical manifestations of Amitriptyline overdose include Cardiac dysrhythmias, severe hypotension, convulsions and CNS depression, including coma. Manifestations of benzodiazepine overdosage include somnolence, confusion, coma and diminished reflexes.

Storage
Store in a cool and dry place, protect from light. Keep all medicines out of reach of the children.

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