Fluderm 150mg

Tablet
Fluconazole
BENHAM pharmaceuticals

Other Strength:
- Fluderm 50mg

Alternative:
- Canazole 150mg
- Mycoder 150mg
- Nispore 150mg
- Candinil 150mg
- Flugal 150mg
- Trigal 150mg



Fluderm
COMPOSITION: Fluderm 50:
Each Tablet contains Fluconazole USP 50 mg.
Fluderm 150: Each Tablet contains Fluconazole USP 150 mg.
PHARMACOLOGY:
Fluconazole is a trinazole, antifungal drug which acts by inhibition of the ergosterol component of the fungal cell membrane. It is active against broad spectrum of fungal pathogens and available for oral administration. Fluconazole acts by inhibiting the synthesis of ergosterol, a major component of the cell membrane of yeast and fungi. Fluconazole is normally administered orally.
Following oral administration; absorption is rapid and extensive, with > 90% of the dose is being absorbed. Bioavailability is the same in the fasting and fed states. The bioavailability of Fluconazole is unaffected by gastric PH. The plasma half life is approximately 30 hours. The plasma portein binding of Fluconazole is low (11 %) and the drug is widely distributed throughout the body. Most of the dose of Fluconazole is excreted as unchanged in the urine and the remining dose is being eliminated in the unine as metabolites.

INDICATION:
It is indicated in the treatment of acute or recurrent vaginal candidiasis, mucosal candidiasis (oropharyngeal candidiasis, oesophagitis candiduria), systemic candidiasis and cryptococcal infections (including meningitis).

DOSAGE AND ADMINISTRATION:
Acute or recurrent vaginal candidiasis
- a single dose of 150 mg. Mucosal candidiasis (except vaginal) 50mg daily (100 mg daily in unusual difficult infections) given for 7-14 days in oropharyngeal candidiasis; for 14-30 days in other mucosal infections (e.g
cesophagetis, candidiuria) Systemic candidiasis and cryptococcal infections (including meningitis)
- 400 mg initially and then 200mg daily; increased if necessary to 400 mg daily; treatment is continued according to response. Child over 1 year
- superficial candidal infections, 1-2 mg/kg body weight daily; systemic candidiasis and cryptococcal infections, 3-6 mg/kg body weight daily (in serious life threatening infections up to 12 mg/kg body weight daily has been given to children age 5-13 years
- max. 400 mg daily).

CONTRAINDICATION:
It is contraindicated to patients hypersensitive to this drug and in advanced liver disease.

PRECAUTION:
Caution should be taken in renal impairment, pregnancy and breast feeding and in raised liver enzymes. The use of Fluconazole in lactating mothers is not recommended.

SIDE EFFECTS:
Nausea, abdominal discomfort, diarrhoea and flatulence, occasional abnormalities of liver enzymes, rarely rash, angioedema and anaphylaxis.

DRUG INTERACTION:
Rifampicin reduces plasma concentration of Fluconazole. Effect of nicoumalone, phenytoin and warfarin is enhanced. Plasma concentrations of sulphonylureas & theophyline is possibly increased.

STORAGE:
Store at normal temparature, protect from light. Keep out of the reach of children.



এই পাতাটি ৩৯১ বার দেখা হয়েছে