Dexaguard 0.1%+0.5%

Ophthalmic Solution
Dexamethasone + Chloramphenicol
Incepta Pharmaceuticals Ltd

Other Strength:

Alternative:
- Chlormet 0.1%+0.5%
- A-Phenicol D 0.1%+0.5%
- Eyephen Plus 0.1%+0.5%
- Dexonex-C 0.1%+0.5%



Dexaguard
Presentation
Each ml eye drops contain Dexamethasone Sodium Phosphate BP equivalent to Dexamethasone 1 mg and Chloramphenicol BP 5 mg.

Description
Dexamethasone is one of the most potent corticosteroids; it is 5 -14 times more potent than prednisolone and 25 - 75 times more potent than cortisone and hydrocortisone. Of paramount importance with regard to local therapy is the fact that dexamethasone is over 2000 times more soluble than hydrocortisone or prednisolone. The addition of chloramphenicol, a broad-spectrum antibiotic, has made this combination yield excellent results in inflammation of the anterior uvea.

Indications
Acute purulent conjunctivitis; fresh inflammation of the superficial and deeper corneal layers and corneal ulceration. Keratitis disciformis and the more deep-seated forms of post-herpetic keratitis. Allergic conjunctivitis, allergic blepharitis. Acute and chronic iritis and iridocyclitis.

Dosage & Administration
One drop, 1 to 4 times daily, into the lower fornix

Side Effects
The local use of dexamethasone over a prolonged period may lead in some cases to secondary glaucoma and the development of complicated cataract

Precautions
Dexamethasone and Chloramphenicol Eye drops must be used under strict medical supervision. Because of the possibility of inducing corneal abscess, fungal keratopathy or glaucoma the patient should be referred to an ophthalmologist if the eye has not responded within 48 hours.

Use in Pregnancy & Lactation
Pregnancy The safety of this combination during pregnancy has not yet been established.
Lactation It is not known whether this ophthalmic suspension is excreted in human milk; therefore caution should be observed when it is administered to a nursing mother

Drug Interaction
Specific drug interaction studies have not been conducted with this combination.

Over Dose
If a rise of intraocular pressure occurs, the treatment has to be discontinued

Commercial Pack
Dexaguard Sterile Eye Drops: Plastic dropper bottle containing 5ml sterile Eye Drops.


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