Tolperisone Hydrochloride

Indications
Treatment of painful musculoskeletal disorders with hypermyotonia and decreased motility, especially those resulting from spinal cord injuries, osteoporosis, arthritis, and spasticity. It has also been effective in lumboischial pain, neurolathyrism, knee arthritis, peripheral circulatory diseases, climacteric muscular and vascular complaints, trismus, myogenous headaches, rheumatic diseases accompanied by muscular hypertonia, spasms, pain, inflammatory symptoms and limited motion, and in the post-surgical treatment of traumatologic patients.

Therapeutic Class
Central Depolarizing muscle relaxants, Centrally acting Skeletal Muscle Relaxants

Description
Tolperisone Hydrochloride is a centrally acting muscle relaxant that has been used for the symptomatic treatment of spasticity and muscle spasm. It effectively reduces muscular hypertonicity, improves peripheral blood flow by vasodilatation and reduces pain

Pharmacology
Tolperisone is a centrally acting muscle relaxant that acts at the reticular formation in the brain stem by blocking voltage-gated sodium and calcium channels

Dosage & Administration
Adult: 150-450 mg daily, administered in 2 or 3 divided doses. The maximum dosage is 450 mg/day.
Children:
3 months to 6 years: 1-2 mg/kg/day in 3 divided doses.
6 years to 14 years: 2-4 mg/kg/day in 3 divided doses

Interaction
Concomitant use of Methocarbamol with Tolperisone Hydrochloride has been reported to cause disturbance of visual accommodation.

Contraindications
Hypersensitivity, Myasthenia Gravis and nursing mother.

Side Effects
Diarrhea, dizziness, drowsiness, dryness of the mouth, fall of blood pressure, fatigue, gastric complaints, headaches, hypersensitivity, itching, muscle pain, muscle weakness, rash, and somnolence.

Pregnancy & Lactation
Tolperisone Hydrochloride should be used in pregnancy according to physician's advice. Tolperisone hydrochloride should not be used during breast-feeding.

Precautions & Warnings
In case of children, the prescribed dose and duration of treatment should closely be observed.

Overdose Effects
Excitability has been noted after ingestion of high doses by children. In suicide studies of three isolated cases, it is believed that ingestion of tolperisone was the cause of death.

Storage Conditions
Tolperisone Hydrochloride should be stored below 30° C. Keep out of reach of children