Magaldrate + Simethicone

Indications
This is indicated to relieve symptoms of dyspepsia, heartburn, acid indigestion, sour stomach, gastroesophageal reflux and hiatal hernia. It is also prescribed in hyperacidity associated with peptic ulcers, gastritis and esophagitis. Magaldrate may be given to children if necessary. Also indicated for the relief of flatulence, abdominal distension and windy colic.

Therapeutic Class
Antacids, Anti-dyspeptic/Carminatives

Pharmacology
This is a combination of Magaldrate and Simethicone. Magaldrate (A combination of Aluminium and Magnesium Hydroxide and Sulfates), which neutralizes gastric acid
extraordinarily quickly without raising the pH above 5-6. It also decreases the activity of pepsin in gastric secretion. Besides this, Simethicone, the another component, enables the gas bubble to coalesce and give relief from flatulence.

Dosage & Administration
Tablet: 1-3 tablet, after meals and at bed time or as directed by the physician.
Suspension: 2-4 teaspoonfuls after 20-60 minutes of meal and before sleep or on the basis of physician’s prescription.

Interaction
It should not be used in patients taking any form of Tetracycline. The drug may cause reduced bio-availability or slower absorption of a number of drugs including propranolol, isoniazid, prednisolone and naproxen.

Contraindications
This is contraindicated in patients with known hypersensitivity to magnesium and aluminium. It is also contraindicated in patients with impaired renal functions.

Side Effects
GI side-effects are uncommon. Occasionally, if excessive amount is consumed, diarrhea, constipation or regurgitation may occur.

Pregnancy & Lactation
This is may be used in pregnancy if indicated. However one should avoid excessive dosage. This may pass into breast milk but has not been reported to cause problem in nursing babies.

Precautions & Warnings
Care should be taken in decreased kidney function, hypophosphataemia and weak people.

Use in Special Populations
Use in children: Not recommended in children under 6 years of age unless, directed by physician.

Overdose Effects
Large dose can cause obstruction. Do not use maximum dose of this product for more than 2 weeks, except under the advice and supervision of a physician.

Storage Conditions
Keep in a cool & dry place. Keep out of the reach of children.