Glucosamine Sulphate + Diacerein

Indications
This is primarily indicated in conditions like Osteoarthritis, Rheumatoid arthritis, Bone & Joint injuries.

Therapeutic Class
Stimulation of Cartilage formation

Pharmacology
Glucosamine is a natural substance produced in the human body and found in certain foods. Glucosamine stimulates the production of glycosaminoglycan & proteoglycan, two essential building blocks of cartilage. Glucosamine acts, as a supplement, as a joint lubricant and shock absorber necessary to maintain healthy cartilage and joint function.
Diacerein is an anti-inflammatory analgesic and antipyretic drug, indicated specially for the treatment of arthritic conditions. It directly inhibits IL-1 synthesis and release in vitro and down modulates IL-1 induced activities and relieves Osteoarthritis.

Dosage & Administration
Adult & Children above 12 years: One tablet (Glucosamine Sulphate 750 mg and Diacerein 50 mg) twice daily for 4-12 weeks, taken with food.
Creatinine Clearance(CrCl) < 30 ml/min: The dose of Diacerein to be reduced.

Interaction
There have been no reports of significant drug interactions of Glucosamine with antibiotics/ antidepressants/ antihypertensives/ nitrates/ antiarrythmics/ anxiolytic/ hypoglycemic agents/ antisecretives. But decreased absorption of Diacerein with aluminium and/ or magnesium hydroxide antacids. Increased risk of diarrhea with laxatives, antibiotics. Avoid co-administration with fibres and phytic acids.

Contraindications
There are no known contraindications for Glucosamine. But proven hypersensitivity to Glucosamine is a contraindication. Diabetics are advised to monitor blood glucose levels regularly when taking Glucosamine. No special studies were formed in patients with renal and/or hepatic insufficiency. The toxicological and pharmacokinetic profile of Glucosamine does not indicate limitations for these patients. However, administration to patients with severe hepatic or renal insufficiency should be under appropriate medical supervision. Children should not be supplemented with Glucosamine. Diacerein or to shellfish (e.g., shrimp, crab); who have diabetes, asthma, alcohol dependence or liver disease. While taking the drug complete blood count, liver function and urinalysis should be monitored regularly. Diacerein is contraindicated in pregnancy, lactation and hypersensitivity to anthraquinone derivatives.

Side Effects
Diarrhea, constipation, epigastric pain, heart burn, nausea, vomiting, headache, skin rashes, drowsiness, intense yellow coloring of urine.

Pregnancy & Lactation
Diacerein is contraindicated in pregnancy and lactation. Glucosamine should not be taken by pregnant women and nursing mothers due to lack of scientific data regarding its effect on fetus and infants.

Precautions & Warnings
Caution should be practiced when administering Glucosamine + Diacerein in those patients who are allergic to Glucosamine and/or Diacerein or to shellfish (e.g., shrimp, crab); who have diabetes, asthma, alcohol dependence or liver disease. Before taking Glucosamine + Diacerein complete blood count, liver function and urinalysis should be monitored regularly.

Overdose Effects
Diarrhea may occur.

Storage Conditions
Store in a cool & dry place, protect from light & moisture.