Clonaben 0.5mg

Tablet
Clonazepam
BENHAM pharmaceuticals

Other Strength:
- Clonaben 2mg
- Clonaben 1mg

Alternative:
- Epitra 0.5mg
- Clonatril 0.5mg
- Clonapin 0.5mg
- Clonium 0.5mg
- Epizam 0.5mg
- Arotril 0.5mg
- Leptic 0.5mg



Clonaben
COMPOSITION:
Clonaben 0.5 mg tablet: Each tablet contains Clonazepam USP 0.5 mg.
Clonaben 1 mg tablet: Each tablet contains Clonazepam USP 1 mg.
Clonaben 2 mg tablet: Each tablet contains Clonazepam USP 2 mg.

PHARMACOLOGY:
Clonazepam has pharmacological properties of the benzodiazepine class of drugs. Clonazepam has sedative, hypnotic and anticonvulsant properties. its basic anticonvulsive properties are also similar to those of other benzodiazepines.

INDICATION:
● Anxiety as well as panic disorder, with or without agoraphobia
● Epilepsy and other seizure disorders
● Alone or as an adjunct in the management of myoclonic and akinetic seizures and petit mal variant(Lennox-Gastaut syndrome). May also be of Some value in patients with absence spells (petit mal) who have failed to respond to succinimides.

DOSAGE & ADMINISTRATION:
Dosage must be determined in each patient according to clinical response and tolerance.
Children: The initial dose for infants and children (up to 10 years of age or 30 kg of body weight) should be between 0.01 and 0.03 mg/kg/day and should not exceed 0.05 mg/kg/day given in two or three divided doses.
Adults: The initial dose for adults should not exceed 1.5 mg/day divided into three doses, Dosage may be increased in increments of 0.5 to 1 mg every three days until seizures are adequately controlled. Maintenance dosage must be individualized for each patient depending upon response A recommended maintenance dose for adults is 8 to 10 mg/day in three divided doses.Dosages in excess of 20 mg/day should be administered with caution. The use of multiple anticonvulsants may result in an increase of depressant adverse effects. This should be borne in mind whenever Clonazepam is added to an already existing anticonvulsant regimen.

CONTRAINDICATION:
Significant liver disease, narrow angle glaucoma, sensitivity to benzodiazepines.
SIDEEFFECT: The most frequently occurring adverse reactions to Clonazepam are referable to CNS depression, drowsiness ataxia. In some cases, these may diminish with time. Behavioral problems and salivation have been noted.

DRUG INTERACTION:
Interactions have been reporated between some benzodiazepines and other anticonvulsants, with changes in the serum concentration. PREGNANCY & LACTATION:
Pregnancy category is ‘C’ The use of Clonazepam durin pregnancy should be avoided. Mothers receiving Clonazepam should not breast feed their infants.

OVERDOSE:
The cardinal manifestations of overdosage are drowsiness and confusion, reduced reflexes and coma. There are minimal effects on respiration, pulse and blood pressure, unless the overdosage is extreme.

STORAGE:
Store in a cool & dry place (below 25⁰ C), protected from light. Keep out of the reach of children.



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